Vascular adenosine monophosphate‐activated protein kinase: Enhancer, brake or both?
| Autor: | Paul M. Vanhoutte, Susan W.S. Leung, Hui Chen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adenosine monophosphate
Potassium Channels Vascular smooth muscle Vasodilation AMP-Activated Protein Kinases Pharmacology Nitric Oxide Toxicology 030226 pharmacology & pharmacy Muscle Smooth Vascular endothelial dysfunction 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine nitric oxide Diabetes Mellitus medicine Animals Humans Hypoglycemic Agents Endothelial dysfunction Protein kinase A endothelial nitric oxide synthase AMPK General Medicine potassium channels medicine.disease Adenosine chemistry Vasoconstriction adenosine monophosphate-activated protein kinase endothelium-dependent hyperpolarization Endothelium Vascular medicine.symptom 030217 neurology & neurosurgery Signal Transduction medicine.drug |
| Zdroj: | Chen, H, Vanhoutte, P M & Leung, S W S 2020, ' Vascular adenosine monophosphate-activated protein kinase : Enhancer, brake or both? ', Basic and Clinical Pharmacology and Toxicology, vol. 127, no. 2, pp. 81-91 . https://doi.org/10.1111/bcpt.13357 |
| ISSN: | 1742-7843 1742-7835 |
| DOI: | 10.1111/bcpt.13357 |
| Popis: | Adenosine monophosphate-activated protein kinase (AMPK), expressed/present ubiquitously in the body, contributes to metabolic regulation. In the vasculature, activation of AMPK is associated with several beneficial biological effects including enhancement of vasodilatation, reduction of oxidative stress and inhibition of inflammatory reactions. The vascular protective effects of certain anti-diabetic (metformin and sitagliptin) or lipid-lowering (simvastatin and fenofibrate) therapeutic agents, of active components of Chinese medicinal herbs (resveratrol and berberine) and of pharmacological agents (AICAR, A769662 and PT1) have been attributed to the activation of AMPK (in endothelial cells, vascular smooth muscle cells and/or perivascular adipocytes), independently of changes in the metabolic profile (eg glucose tolerance and/or plasma lipoprotein levels), leading to improved endothelium-derived nitric oxide-mediated vasodilatation and attenuated endothelium-derived cyclooxygenase-dependent vasoconstriction. By contrast, endothelial AMPK activation with pharmacological agents or by genetic modification is associated with reduced endothelium-dependent relaxations in small blood vessels and elevated systolic blood pressure. Indeed, AMPK activators inhibit endothelium-dependent hyperpolarization (EDH)-type relaxations in superior mesenteric arteries, partly by inhibiting endothelial calcium-activated potassium channel signalling. Therefore, AMPK activation is not necessarily beneficial in terms of endothelial function. The contribution of endothelial AMPK in the regulation of vascular tone, in particular in the microvasculature where EDH plays a more important role, remains to be characterized. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|