Pathobiology of pancreatic cancer: implications on therapy
| Autor: | Ivonne Regel, Simone Benitz, Jörg Kleeff, Irene Esposito, Simone Hausmann |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Combination therapy Antineoplastic Agents Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine Cancer stem cell Pancreatic cancer Tumor Microenvironment medicine Animals Humans Pharmacology (medical) Molecular Targeted Therapy Gene Rearrangement Tumor microenvironment business.industry Gene rearrangement medicine.disease Phenotype Pancreatic Neoplasms 030104 developmental biology Oncology Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer cell Immunology Neoplastic Stem Cells Cancer research business Reprogramming |
| Zdroj: | Expert Review of Anticancer Therapy. 16:219-227 |
| ISSN: | 1744-8328 1473-7140 |
| DOI: | 10.1586/14737140.2016.1129276 |
| Popis: | Although the concept of tumor heterogeneity was established several decades ago, the interest in this topic is still unbroken. With the identification of inter- and intratumoral genomic rearrangements and the detection of cancer stem cells (CSCs) through phenotypic variations of cancer cells there are increasing options for pancreatic cancer therapy. Indeed, some pre-clinical studies have shown promising results in the treatment of drug-resistant CSCs, whereby a few strategies were already tested in clinical trials. Basically, CSCs are influenced by the tumor microenvironment and an epigenetic reprogramming to gain stem cell-like characteristics. Targeting options inhibiting the epithelial-mesenchymal crosstalk or promoting epigenetic-driven differentiation of CSCs to a less aggressive phenotype raised the possibilities of further therapeutic applications, which will be discussed in this review. |
| Databáze: | OpenAIRE |
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