Pyrazole NNRTIs 1: design and initial optimisation of a novel template

Autor:	Charles E. Mowbray, Anthony Wood, Manos Perros, Romuald Corbau, Stupple Paul Anthony, Catherine Burt, Rob Webster, Isabelle Tran
Rok vydání:	2009
Předmět:	Molecular model Stereochemistry Anti-HIV Agents Clinical Biochemistry Pharmaceutical Science Pyrazole Biochemistry Chemical synthesis chemistry.chemical_compound Structure-Activity Relationship Drug Discovery medicine Humans Molecular Biology Reverse-transcriptase inhibitor RNA-Directed DNA Polymerase Organic Chemistry Wild type virus diseases Nucleotidyltransferase Reverse transcriptase HIV Reverse Transcriptase chemistry Drug Design Microsomes Liver Molecular Medicine Pyrazoles Reverse Transcriptase Inhibitors medicine.drug
Zdroj:	Bioorganicmedicinal chemistry letters. 19(19)
ISSN:	1464-3405
Popis:	The design and synthesis of a novel series of non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) based on a pyrazole template is described. These compounds are active against wild type reverse transcriptase (RT) and retain activity against clinically important mutants.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae5c45485d496c3861bcd3d4f846411 https://pubmed.ncbi.nlm.nih.gov/19709880 Zobrazit plný text záznamu Full Text from ScienceDirect