The link between COVID-19 and VItamin D (VIVID): a systematic review and meta-analysis
| Autor: | Marlene Chakhtoura, Maya Basbous, Aya Bassatne, Maya Rahme, Ola El Zein, Ghada El-Hajj Fuleihan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endocrinology Diabetes and Metabolism Nutritional Status 030209 endocrinology & metabolism Placebo vitamin D deficiency Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine Vitamin D and neurology Medicine Humans Vitamin D Mortality ICU admission business.industry Mortality rate COVID-19 Vitamins medicine.disease Vitamin D Deficiency Clinical trial Hospitalization 030104 developmental biology chemistry Meta-analysis Dietary Supplements Calcifediol business Cholecalciferol |
| Zdroj: | Metabolism |
| ISSN: | 1532-8600 0026-0495 |
| Popis: | BACKGROUND: Disease severity and mortality rates due to COVID-19 infection are greater in the elderly and chronically ill patients, populations at high risk for vitamin D deficiency. Vitamin D plays an important role in immune function and inflammation. This systematic review and meta-analysis assesses the impact of vitamin D status and supplementation on COVID-19 related mortality and health outcomes. METHODS: We searched four databases until December 18th 2020, and trial registries until January 20th 2021. Two reviewers screened the studies, collected data, assessed the risk of bias, and graded the evidence for each outcome across studies, independently and in duplicate. Pre-specified outcomes of interest were mortality, ICU admission, invasive and non-invasive ventilation, hospitalization, time of hospital stay, disease severity and SARS-CoV-2 positivity. We only included data from peer-reviewed articles in our primary analyses. RESULTS: We identified 31 peer-reviewed observational studies. In our primary analysis, there was a positive trend between serum 25(OH)D level |
| Databáze: | OpenAIRE |
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