Influence of moderate maternal nutrition restriction on the fetal baboon metabolome at 0.5 and 0.9 gestation
| Autor: | Franca F. Kirchberg, Wolfgang Peissner, Christian Hellmuth, Berthold Koletzko, Ulrike Harder, Olaf Uhl, P. W. Nathanielsz |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Gestational Age 030209 endocrinology & metabolism Fatty Acids Nonesterified Mass Spectrometry 03 medical and health sciences chemistry.chemical_compound Fetus 0302 clinical medicine NEFA Pregnancy Carnitine Internal medicine medicine Animals Humans Metabolomics Phospholipids Caloric Restriction chemistry.chemical_classification Nutrition and Dietetics Chemistry Malnutrition Gluconeogenesis Fatty acid Maternal Nutritional Physiological Phenomena Metabolism Adaptation Physiological Disease Models Animal 030104 developmental biology Endocrinology Liver Metabolome Gestation Female Cardiology and Cardiovascular Medicine Biomarkers PCAA Chromatography Liquid Papio medicine.drug |
| Zdroj: | Nutrition, Metabolism and Cardiovascular Diseases. 26:786-796 |
| ISSN: | 0939-4753 |
| Popis: | Background and aims Moderately reduced maternal nutrient availability during pregnancy has adverse effects on the fetuses' growth and metabolism during and after pregnancy. The aim of this study was to explore effects of maternal nutrition restriction (MNR) on key metabolites of the fetal energy metabolism, particularly amino acids (AA), nonesterified fatty acids (NEFA), acylcarnitines and phospholipids. These effects may reflect mechanisms relating MNR to later adverse outcomes. Methods and results Plasma and liver samples of fetal baboons, whose mothers were fed ad libitum (CTR) or MNR (70% of CTR), were collected at 0.5 and 0.9 gestation (G – term 184 days). Metabolites were measured with liquid chromatography coupled to mass spectrometry. In both, CTR and MNR, fetal metabolic profiles changed markedly between 0.5G and 0.9G. Fetal liver glucose concentrations were strongly increased. Hepatic levels of NEFA, sphingomyelins, and alkyl-linked phospholipids increased while plasma NEFA and acyl-linked phospholipids levels decreased with progression of gestation. At 0.5G, MNR fetal plasma levels of short- and medium-chain acylcarnitines were elevated, but did no longer differ between groups at 0.9G. At 0.9G, plasma levels of methionine and threonine as well as hepatic threonine levels were lower in the MNR group. Conclusion Small differences in the concentrations of plasma and liver metabolites between MNR and CTR fetuses reflect good adaptation to MNR. Fetal liver metabolic profiles changed markedly between the two gestation stages, reflecting enhanced liver glucose and lipid levels with advancing gestation. Decreased concentrations of AA suggest an up-regulation of gluconeogenesis in MNR. |
| Databáze: | OpenAIRE |
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