Pain and health-related quality of life in patients with advanced solid tumours and bone metastases: integrated results from three randomized, double-blind studies of denosumab and zoledronic acid
| Autor: | Gavin Marx, Alison Stopeck, Ada Braun, Charles S. Cleeland, Roger von Moos, Felipe G. Palazzo, Blair Egerdie, Jean-Jacques Body, Donald L. Patrick, Karen Chung, Lesley Fallowfield, Yi Qian, Janet E. Brown, Danail Damyanov |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Pain medicine Analgesic Pain Bone Neoplasms Breast Neoplasms Antibodies Monoclonal Humanized Zoledronic Acid law.invention Young Adult Double-Blind Method Randomized controlled trial Quality of life law Neoplasms Internal medicine medicine Humans In patient Aged Aged 80 and over Analgesics Bone Density Conservation Agents Diphosphonates business.industry Imidazoles Middle Aged Clinical trial Prostatic Neoplasms Castration-Resistant Denosumab Zoledronic acid Quality of Life Female business medicine.drug |
| Zdroj: | Supportive Care in Cancer. 21:3497-3507 |
| ISSN: | 1433-7339 0941-4355 |
| DOI: | 10.1007/s00520-013-1932-2 |
| Popis: | This analysis evaluated patient-reported outcomes and analgesic use in patients with bone metastases from solid tumours across three comparative studies of denosumab and zoledronic acid.Pooled data were analysed from three identically designed double-blind phase III studies comparing subcutaneous denosumab 120 mg with intravenous zoledronic acid 4 mg monthly in patients with bone metastases from breast cancer (n = 2,046), castration-resistant prostate cancer (n = 1,901) or other solid tumours (n = 1,597). Pain severity, pain interference, health-related quality of life and analgesic use were quantified.At baseline, approximately half of patients had no/mild pain (53 % [1,386/2,620] denosumab; 50 % [1,297/2,578] zoledronic acid). Denosumab delayed onset of moderate/severe pain by 1.8 months (median, 6.5 vs 4.7 months; hazard ratio, 0.83; 95 % CI, 0.76-0.92; p 0.001; 17 % risk reduction) and clinically meaningful increases in overall pain interference by 2.6 months (median, 10.3 vs 7.7 months; hazard ratio, 0.83; 95 % CI, 0.75-0.92; p 0.001; 17 % risk reduction) compared with zoledronic acid. Strong opioid use and worsening of health-related quality of life were less common with denosumab.Across three large studies of patients with advanced solid tumours and bone metastases, denosumab prevented progression of pain severity and pain interference more effectively than zoledronic acid. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink