Estimation of Aortic Time-enhancement Curve in Pharmacokinetic Analysis: Dynamic Study by Multi-detector Row Computed Tomography
| Autor: | Masayuki Suzuki, Eiji Kidoya, Isao Yamaguchi, Hiroyuki Hayashi, Kyoji Higashimura |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Cardiac output TEC Contrast Media Computed tomography Models Biological Time Pharmacokinetics medicine.artery medicine Humans Computer Simulation Tissue Distribution Cardiac Output Compartment (pharmacokinetics) Aorta medicine.diagnostic_test business.industry Body Weight General Medicine Middle Aged Contrast medium Organ Specificity Injections Intravenous Female Radiology Tomography business Tomography Spiral Computed Software Biomedical engineering |
| Zdroj: | Japanese Journal of Radiological Technology. 63:621-627 |
| ISSN: | 1881-4883 0369-4305 |
| Popis: | This paper presents an introduction to the development of software that provides a physiologic model of contrast medium enhancement by incorporating available physiologic data and contrast medium pharmacokinetics to predict an organ-specific aortic time-enhancement curve(TEC)in computed tomography(CT)with various contrast medium injection protocols in patients of various heights, weights, cardiac output levels, and so on. The physiologic model of contrast medium enhancement was composed of six compartments for early contrast enhancement pharmacokinetics. Contrast medium is injected via the antecubital vein and distributed to the right side of the heart, the pulmonary compartment, the left side of the heart, and the aorta. It then circulates back to the right side of the heart via the systemic circulation. A computer-based, compartmental model of the aortic system was generated using human physiologic parameters and six differential equations to describe the transport of contrast medium. Aortic TEC generated by the computer-based physiologic model of contrast medium enhancement showed validity and agreement with clinical data and findings published previously. A computer-based physiologic model that may help predict organ-specific CT contrast medium enhancement for different injection protocols was developed. Such a physiologic model may have multiple clinical applications. |
| Databáze: | OpenAIRE |
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