Antimalarial Activity of Hydromethanolic Crude Extract and Chloroform Fraction of Brucea antidysenterica Leaves in Plasmodium berghei-Infected Mice
| Autor: | Kefyalew Ayalew Getahun, Tezera Jemere Aragaw |
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| Rok vydání: | 2021 |
| Předmět: |
Brucea antidysenterica
Chloroform Article Subject Traditional medicine Inoculation Fraction (chemistry) Parasitemia Biology medicine.disease biology.organism_classification Other systems of medicine chemistry.chemical_compound Complementary and alternative medicine chemistry In vivo parasitic diseases medicine Plasmodium berghei Antimalarial Agent RZ201-999 Research Article |
| Zdroj: | Evidence-based Complementary and Alternative Medicine : eCAM Evidence-Based Complementary and Alternative Medicine, Vol 2021 (2021) |
| ISSN: | 1741-4288 1741-427X |
| DOI: | 10.1155/2021/2089114 |
| Popis: | Background. Different parts of Brucea antidysenterica are used in traditional and alternative medicine in Ethiopia for the treatment of different health problems including malaria and have good in vitro antimalarial activity. However, no in vivo study was conducted to substantiate the claim. Our study planned to determine the antimalarial effect of B. antidysenterica extract. Methods. Swiss albino mice (6–8 weeks old, 20–28 g) were inoculated with Plasmodium berghei. Different doses of both hydromethanolic extract and chloroform fraction were orally given at 100, 200, and 400 mg/kg/day. Results. The parasitemia suppression percent of hydromethanolic crude extract and chloroform fraction in chemosuppressive tests ranged between 33.48 and 75.93% and 38.32 and 76.64%, respectively. The hydromethanolic crude extract and chloroform fraction exhibited the curative effect of 46.75–70.91% and 50.30–80.06% parasitemia suppression, respectively ( p |
| Databáze: | OpenAIRE |
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