An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes
| Autor: | Ritu Bhalla, Njabulo J. Gumede, Zodwa Dlamini, Chindo Hicks, Lucio Miele, Oliver Sartor, Ritika Ramani |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
primary metastatic prostate cancer Genome-wide association study Genomics Computational biology Proteomics Bioinformatics Metastasis 03 medical and health sciences Prostate cancer 0302 clinical medicine medicine Genetic predisposition GWAS Integrative genomics analysis Genetic association Original Research Pharmacology lcsh:R5-920 business.industry Biochemistry (medical) Cancer medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Molecular Medicine lcsh:Medicine (General) business |
| Zdroj: | Biomarker Insights Biomarker Insights, Vol 12 (2017) |
| ISSN: | 1177-2719 |
| Popis: | High-throughput genotyping has enabled discovery of genetic variants associated with an increased risk of developing prostate cancer using genome-wide association studies (GWAS). The goal of this study was to associate GWAS information of patients with primary organ–confined and metastatic prostate cancer using gene expression data and to identify molecular networks and biological pathways enriched for genetic susceptibility variants involved in the 2 disease states. The analysis revealed gene signatures for the 2 disease states and a gene signature distinguishing the 2 patient groups. In addition, the analysis revealed molecular networks and biological pathways enriched for genetic susceptibility variants. The discovered pathways include the androgen, apoptosis, and insulinlike growth factor signaling pathways. This analysis established putative functional bridges between GWAS discoveries and the biological pathways involved in primary organ–confined and metastatic prostate cancer. |
| Databáze: | OpenAIRE |
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