Serum immunoglobulin levels in paediatric patients with pneumonia
| Autor: | K.J. Nathoo, L.R. Mazengera, B.J.M. Zegers |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Zimbabwe
medicine.medical_specialty Immunoglobulin levels Reference range Pilot Projects Internal medicine HIV Seropositivity medicine Humans In patient Child Paediatric patients biology business.industry Infant General Medicine Pneumonia medicine.disease P24 antigen Immunoglobulin A Cross-Sectional Studies Immunoglobulin M Child Preschool Immunoglobulin G Immunology Elevated IgA biology.protein Antibody business |
| Zdroj: | Central African Journal of Medicine; Vol 45, No 11 (1999) |
| ISSN: | 0008-9176 |
| Popis: | OBJECTIVE To determine levels of serum immunoglobulins IgG, IgM and IgA in patients admitted with pneumonia to Harare Central Hospital paediatric wards. DESIGN A cross sectional pilot study. SETTING Harare Central Hospital, Department of Immunology, University of Zimbabwe; Department of Paediatrics, University of Zimbabwe; Immunology Laboratory, University of Utrecht (The Netherlands). SUBJECTS 71 paediatric patients. MAIN OUTCOME MEASURES Immunoglobulin profiles for children with pneumonia. RESULTS Of the 71 children tested, 43 had high IgG levels of between two and half and five times the upper end of the normal age-matched reference range. While the same 43 children with high IgG had similarly elevated levels of IgM, only 25 of them had elevated IgA levels. Of this group of 43 children with hypergammaglobulinaemia, all but one, had antibodies to human immunodeficiency virus (HIV), 50% of whom had detectable levels of p24 antigen in their sera. A small minority, 4% of the 71 patients, had very low levels of total immunogloblins. CONCLUSIONS High levels of total immunoglobulins occur frequently in children with pneumonia and are associated with the presence of HIV 1/2 antibodies and also p24 antigen. |
| Databáze: | OpenAIRE |
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