COVID-19 Infection in Kidney Transplant Recipients: Disease Incidence and Clinical Outcomes
| Autor: | Corinne Antoine, Christine Randoux, Océane Le Goff, Evangeline Pillebout, Imad Abboud, Daniele Pievani, Blandine Denis, Alexandra Delion, Denis Glotz, Carmen Lefaucheur, Michelle Elias, Clarisse Greze, Eric Daugas, Kevin Louis |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Pneumonia Viral Population 030232 urology & nephrology Comorbidity 030230 surgery Risk Assessment Cohort Studies Immunocompromised Host 03 medical and health sciences 0302 clinical medicine Clinical Research Diabetes mellitus Internal medicine Outcome Assessment Health Care medicine Risk of mortality Humans Prospective Studies education Pandemics Kidney transplantation Aged Infection Control education.field_of_study business.industry Incidence Mortality rate COVID-19 General Medicine Odds ratio Middle Aged medicine.disease Kidney Transplantation Survival Analysis Transplant Recipients Nephrology Kidney Failure Chronic Population study Female France Coronavirus Infections business |
| Zdroj: | J Am Soc Nephrol |
| ISSN: | 1533-3450 1046-6673 |
| DOI: | 10.1681/asn.2020050639 |
| Popis: | BACKGROUND: COVID-19 has been associated with high morbidity and mortality in kidney transplant recipients. However, risk factors for COVID-19 disease in patients with kidney transplants remain poorly defined. METHODS: We enrolled patients who underwent kidney transplantation and were actively followed up in two hospitals in Paris on March 1st, 2020. Patients were screened for baseline and transplant characteristics, functional parameters, comorbidities, and immunosuppressive therapies. COVID-19 disease was assessed. Patients were followed up during the pandemic until April 30th, 2020 by the COVID-19 SLS KT survey program, including teleconsulting, at-home monitoring for patients with COVID-19, and a dedicated phone hotline platform. RESULTS: Among 1216 patients with kidney transplants enrolled, 66 (5%) patients were identified with COVID-19 disease, which is higher than the incidence observed in the general population in France (0.3%). Their mean age was 56.4±12.5 years, and 37 (56%) patients were men. The following factors were independently associated with COVID-19 disease: non-White ethnicity (adjusted odds ratio [OR], 2.17; 95% confidence interval [95% CI], 1.23 to 3.78; P=0.007), obesity (OR, 2.19; 95% CI, 1.19 to 4.05; P=0.01), asthma and chronic pulmonary disease (OR, 3.09; 95% CI, 1.49 to 6.41; P=0.002), and diabetes (OR, 3.33; 95% CI, 1.92 to 5.77; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|