The Role of CC10 in Pulmonary Carcinogenesis: From a Marker to Tumor Suppression
| Autor: | Francesco J. DeMayo, Carol L. K. Sabourin, R. Ilona Linnoila, Hanspeter Witschi, Eva Szabo, Al Malkinson |
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| Rok vydání: | 2006 |
| Předmět: |
Pathology
medicine.medical_specialty Lung Neoplasms Cell Synaptophysin Down-Regulation Antineoplastic Agents Mice Transgenic Respiratory Mucosa Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Mice History and Philosophy of Science Downregulation and upregulation Biomarkers Tumor Tumor Cells Cultured medicine Animals Humans Uteroglobin Genes Tumor Suppressor Progenitor cell Lung Carcinogen Regulation of gene expression General Neuroscience Proteins respiratory system Epithelium Gene Expression Regulation Neoplastic Disease Models Animal medicine.anatomical_structure Cancer research Carcinogenesis Signal Transduction |
| Zdroj: | Annals of the New York Academy of Sciences. 923:249-267 |
| ISSN: | 1749-6632 0077-8923 |
| Popis: | CC10 is infrequently expressed in human non-small cell lung cancers (NSCLCs), despite being abundantly produced by progenitor cells for normal and neoplastic epithelium. Many abnormalities in the surrounding lung associated with field carcinogenesis, which reflect prolonged exposure to such carcinogens as tobacco smoke, also revealed altered expression of CC10. Exposure of hamsters and mice to the tobacco-specific carcinogen NNK led to reduced CC10 expression, which was partially reversible. Overexpression of CC10 in immortalized bronchial epithelial cells delayed the induction of anchorage-independent growth in response to NNK. The data suggest that downregulation of CC10 contributes to carcinogenesis because CC10 antagonizes the neoplastic phenotype. |
| Databáze: | OpenAIRE |
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