Actinomycin D injected into the hippocampus of chicks: Effects upon imprinting
| Autor: | Stephen D. Codish |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
medicine.medical_specialty
Time Factors Behavior Animal Experimental and Cognitive Psychology Imprinting Psychological Memory retention Hippocampus Stimulation Chemical Behavioral Neuroscience Endocrinology Animals Newborn Memory Internal medicine Dactinomycin medicine Animals RNA Imprinting (psychology) Psychology Chickens Neuroscience |
| Zdroj: | Physiology & Behavior. 6:95-96 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/0031-9384(71)90024-2 |
| Popis: | An experimental method to test the effect of Actinomycin D on a permanent form of memory is reported here. Injections of Actinomycin D in the hippocampus of chicks 30 min after imprinting blocked the formation of memory of the imprinting response when tested at 4 days of age whereas injections 1 day after imprinting did not. Since the imprinting response is known to persist for months after its establishment at an early age and because the lethal effects of the drug have prevented examination of memory retention over extended periods of time, this experimental design is advantageous in demonstrating that Actinomycin D, an inhibitor of RNA synthesis, impairs formation of long-term memory. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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