Decreased concentrations of CGRP in Leishmania major murine cutaneous leishmaniasis
| Autor: | Elvar Theodorsson, K. Nordlind, Ahmed Abdelaziz Ahmed, Mahmood Ahmed |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Calcitonin Gene-Related Peptide Central nervous system Radioimmunoassay Leishmaniasis Cutaneous Spleen Calcitonin gene-related peptide Mice Cutaneous leishmaniasis Dorsal root ganglion Internal medicine Ganglia Spinal medicine Animals Leishmania major Chromatography High Pressure Liquid Skin Mice Inbred BALB C biology General Neuroscience medicine.disease Leishmania biology.organism_classification Mice Inbred C57BL Endocrinology medicine.anatomical_structure Nociception Immunology Female Disease Susceptibility Lymph Nodes |
| Zdroj: | Neuroscience letters. 246(3) |
| ISSN: | 0304-3940 |
| Popis: | The expression of the sensory neuropeptide calcitonin gene-related peptide (CGRP) in the skin, secondary lymphoid organs and dorsal root ganglia (L4‐L6) in Leishmania major-induced inflammation was evaluated by radioimmunoassay. The investigation was conducted on two mouse strains, the susceptible BALB/c and the resistant C57BL/6. The CGRP concentration in the inflamed skin of both mouse strains was decreased as early as 1 week postinfection, compared to controls. A further reduction was observed in both mouse strains throughout the 9-week study period, but was more evident in the susceptible strain. The CGRP concentration was increased in the ipsilateral dorsal root ganglia (L4‐L6) of mice of the resistant strain 1 week postinfection, while no change was observed in the susceptible strain. In the remaining part of the study period there was a reduction in CGRP in the ipsilateral dorsal root ganglia of both mouse strains. In the spleen, a reduction was noted in the infected BALB/c at all measurement times (significant at 6 and 9 weeks), while no change was observed in C57BL/6 strain. These findings may indicate a regulatory function of CGRP in the pathophysiology of murine cutaneous leishmaniasis and hence in the disease outcome. The reduction in CGRP might also explain the defective nociception observed in patients with cutaneous leishmaniasis. © 1998 Elsevier Science Ireland Ltd. |
| Databáze: | OpenAIRE |
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