Elevated levels of IL-37 correlate with T cell activation status in rheumatoid arthritis patients
| Autor: | Dina Ragab, Sameh A. Mobasher, Elham Shabaan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty CD3 Complex CD3 medicine.medical_treatment T cell Dipeptidyl Peptidase 4 T-Lymphocytes Immunology Lymphocyte Activation Biochemistry Peripheral blood mononuclear cell Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Immunology and Allergy Humans Molecular Biology chemistry.chemical_classification medicine.diagnostic_test biology business.industry Hematology Middle Aged medicine.disease Peripheral blood 030104 developmental biology Endocrinology Enzyme Cytokine medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Rheumatoid arthritis Erythrocyte sedimentation rate biology.protein Female business Interleukin-1 |
| Zdroj: | Cytokine. 113 |
| ISSN: | 1096-0023 |
| Popis: | Objective To assess the association between serum levels of IL-37 in rheumatoid arthritis patients and percentage of peripheral blood T lymphocytes expressing the activation marker CD26 and investigate their correlation with disease activity. Methods The study included 48 rheumatoid arthritis patients and 42 age and sex matched healthy controls. Serum levels of IL-37 were determined using enzyme linked immunosorbent assay while percentage of CD3+CD26+T cells in peripheral blood mononuclear cells was assayed using flowcytometry. Results Serum levels of IL-37, as well as the percentage of CD3+CD26+T cells, were significantly higher in rheumatoid arthritis patients than in healthy controls. Also, serum IL-37 levels were higher in patients with severe disease activity than patients with moderate and low disease activity. In rheumatoid arthritis patients, both serum levels of IL-37 and percentage of CD3+CD26+T cells correlated with disease activity (DAS28), C-reactive protein levels and erythrocyte sedimentation rate. In addition, serum levels of the anti-inflammatory cytokine IL-37 positively correlated with the percentage of CD3+CD26+T cells in peripheral blood of rheumatoid arthritis patients. Conclusion Our results indicate a strong correlation between serum levels of IL-37 and frequency of activated T cells in peripheral blood of rheumatoid arthritis patients. Our results suggest that in an active disease status, activated T lymphocytes may be a contributing source to the elevated levels of IL-37 trying to down-regulate the active inflammatory process. |
| Databáze: | OpenAIRE |
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