Omeprazole plus Amoxicillin for Cure of Helicobacter pylori Infection Factors Influencing the Treatment Success
| Autor: | J. Labenz, G. Börsch, F. Leverkus |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Helicobacter pylori infection medicine.medical_specialty medicine.drug_class Spirillaceae medicine.medical_treatment Antibiotics Gastroenterology Helicobacter Infections Internal medicine Humans Medicine Prospective Studies Stomach Ulcer Dyspepsia Omeprazole Aged Antibacterial agent Analysis of Variance Clinical Trials as Topic Chemotherapy Helicobacter pylori biology business.industry Amoxicillin Middle Aged biology.organism_classification Logistic Models Treatment Outcome Duodenal Ulcer Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Scandinavian Journal of Gastroenterology. 29:1070-1075 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365529409094890 |
| Popis: | Omeprazole plus amoxicillin may cure Helicobacter pylori infection. However, the published results vary rather widely, and the factors influencing the treatment success remain unclear.Four hundred and twenty-three H. pylori-positive patients were treated with 1- or 2-week regimens comprising 40 mg or 80 mg omeprazole and amoxicillin in 11 prospective protocols. A complete set of data was available for 405 patients (ulcer disease, n = 383; dyspepsia, n = 22) and was submitted to uni- and multi-variate statistical analyses to elucidate the factors affecting the cure rates of the infection; 18 patients were lost to follow-up.The overall proportion of H. pylori cure was 76%. Insufficient compliance (p0.001), a short duration of treatment (p0.001), smoking (p = 0.003), and omeprazole pretreatment (p = 0.041) were the significant independent factors predicting treatment failure, whereas advanced age (p = 0.002), high scores of grade and of activity of gastritis (p = 0.035 and p = 0.019, respectively), and gastric ulcer disease (p = 0.058) were independent factors predicting treatment success.Several patient- and therapy-related factors diminish or increase the rate of H. pylori cure obtained by omeprazole/amoxicillin. These should be considered in future studies comparing different treatment regimens for curing H. pylori infection and also when designing treatment regimens applicable for routine clinical practice. |
| Databáze: | OpenAIRE |
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