Effects of pneumoperitoneum on kidney injury biomarkers: A randomized clinical trial

Autor: Gabriel dos Santos Tarquinio, Marcos Antonio Marton Filho, Norma Sueli Pinheiro Módolo, Paulo do Nascimento, Paulo Ferreira Mega, Rodrigo Leal Alves
Přispěvatelé: Universidade Estadual Paulista (Unesp), Centro Universitário Estácio de Ribeirão Preto, Universidade Federal da Bahia (UFBA), Clínica de Anestesiologia de Ribeirão Preto (CARP), Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
medicine.medical_treatment
Hemodynamics
Blood Pressure
Biochemistry
Vascular Medicine
law.invention
Tertiary Care Centers
Pneumoperitoneum
Randomized controlled trial
law
Medicine and Health Sciences
Medicine
Single-Blind Method
Postoperative Period
Multidisciplinary
biology
Drugs
Middle Aged
Laparoscopic Cholecystectomy
Urinary Biomarkers
Cholecystectomy
Laparoscopic
Biomarker (medicine)
Female
Kidney Diseases
Anatomy
Research Article
Adult
medicine.medical_specialty
Science
Urology
Surgical and Invasive Medical Procedures
Digestive System Procedures
Lipocalin-2
Pain Management
Humans
Cholecystectomy
Cystatin C
Anesthetics
Aged
Pharmacology
business.industry
Biology and Life Sciences
Kidneys
Renal System
medicine.disease
Clinical trial
Blood pressure
biology.protein
Laparoscopy
business
Biomarkers
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0247088 (2021)
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 1932-6203
Popis: Made available in DSpace on 2021-06-25T10:53:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-02-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background Increased intra-abdominal pressure causes hemodynamic changes that may affect renal biomarkers. Methods This randomized, single-blind, single-center clinical trial recruited patients undergoing laparoscopic cholecystectomy at a tertiary care center in Brazil. They were randomly allocated to a standard intra-abdominal pressure group (P10-12, 10-12 mm Hg) and a low intra-abdominal pressure group (P6-8, 6-8 mm Hg). The primary outcome was the change in neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C levels measured at the beginning of the procedure (T0), at the end of the procedure (T1), and 24 hours after the procedure (T2). P-values < 0.05 were considered statistically significant. Results In total, 64 patients completed the study-33 were given standard pressure and 31 were given low pressure. There was no significant difference in the biomarker between the groups (P = 0.580), but there was a significant difference between the time points with elevation at T1 (P < 0.001). Similar to NGAL, cystatin C had an elevation at T1 in both groups (P = 0.021), but no difference was found when comparing the groups. Conclusions In laparoscopic cholecystectomy, pneumoperitoneum increases NGAL and cystatin C levels intraoperatively, and the use of low-pressure pneumoperitoneum does not change the course of these biomarkers. Department of Surgical Specialties and Anesthesiology Botucatu School of Medicine Universidade Estadual Paulista (UNESP) Centro Universitário Estácio de Ribeirão Preto Department of Anesthesiology São Rafael Hospital Federal University of Bahia Clínica de Anestesiologia de Ribeirão Preto (CARP) School of Medicine Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) Department of Surgical Specialties and Anesthesiology Botucatu School of Medicine Universidade Estadual Paulista (UNESP) FAPESP: 2017/27032-0
Databáze: OpenAIRE
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