A case of varicella-zoster myelopathy
| Autor: | N. Sasaki, K. Morita, H. Minami, T. Suzutani, R. Gotoh, Hitoshi Aizawa, Osamu Yahara, K. Tobise |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Herpesvirus 3 Human viruses medicine.disease_cause Polymerase Chain Reaction Spinal Cord Diseases Virus law.invention Myelopathy Cerebrospinal fluid law Humans Medicine Polymerase chain reaction Aged business.industry Varicella zoster virus virus diseases General Medicine medicine.disease Virology Herpes simplex virus Neurology DNA Viral Neurology (clinical) Viral disease business Nested polymerase chain reaction |
| Zdroj: | Acta Neurologica Scandinavica. 93:470-472 |
| ISSN: | 1600-0404 0001-6314 |
| DOI: | 10.1111/j.1600-0404.1996.tb00028.x |
| Popis: | Introduction - Early diagnosis of neurological complications of varicellazoster virus (VZV) is important because of its treatability. We performed polymerase chain reaction (PCR) to detect VZV-DNA from the cerebrospinal fluid (CSF) of a patient with myelopathy. Patient & methods - A 69-year-old man developed sensory disturbances in the lower extremities and bladder-bowel disturbances, followed by cutaneous zoster on his left arm. Polymerase chain reaction was applied to identify the viral DNA in CSF. Results - The increased antibody index of VZV and herpes simplex virus (HSV) in the CSF suggested intrathecal synthesis of IgG antibodies to these viruses. VZV-DNA was detected in the CSF by nested PCR, but neither HSV-1 nor HSV-2 DNA was detected in CSF. He was successfully treated with acyclovir and prednisolone. Conclusion - PCR may be a useful tool for the diagnosis of VZV myelopathy. |
| Databáze: | OpenAIRE |
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