Associations of cells from both innate and adaptive immunity with lower nerve conduction velocity: the Maastricht Study
| Autor: | Jos P. H. Reulen, Dan Ziegler, Haifa Maalmi, Werner H. Mess, Coen D.A. Stehouwer, Casper G. Schalkwijk, Hans H.C.M. Savelberg, Nicolaas C. Schaper, Christian Herder, Jeroen H. P. M. van der Velde, Kristiaan Wouters, Michael Roden |
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| Přispěvatelé: | Interne Geneeskunde, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, Nutrition and Movement Sciences, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Klinische Neurowetenschappen, MUMC+: HZC Klinische Neurofysiologie (5), MUMC+: HZC Med Staf Spec Klinische Neurofys (9), RS: Carim - B06 Imaging, MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Reumatologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Hematologie (9), MUMC+: MA Maag Darm Lever (9), MUMC+: MA Endocrinologie (9), MUMC+: MA Interne Geneeskunde (3), RS: Carim - V02 Hypertension and target organ damage |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
SCHWANN-CELLS
DIABETIC PERIPHERAL NEUROPATHY diagnosis Endocrinology Diabetes and Metabolism T cell Neural Conduction 030209 endocrinology & metabolism PROGRESSION Adaptive Immunity CD8-Positive T-Lymphocytes T-CELL Nerve conduction velocity Diseases of the endocrine glands. Clinical endocrinology ANTIGENS 03 medical and health sciences 0302 clinical medicine Immune system Antigen cohort studies subclinical inflammation medicine Humans Pathophysiology/Complications 030304 developmental biology 0303 health sciences business.industry neurology CYTOKINES Acquired immune system medicine.disease RC648-665 Cross-Sectional Studies medicine.anatomical_structure Diabetes Mellitus Type 2 type 2 CORNEAL CONFOCAL MICROSCOPY inflammation Immunology diabetes mellitus POLYNEUROPATHY business Polyneuropathy CD8 Sensory nerve |
| Zdroj: | BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021) BMJ Open Diabetes Research & Care, 9(1):001698. BMJ Publishing Group BMJ Open Diabetes Research & Care |
| ISSN: | 2052-4897 |
| DOI: | 10.1136/bmjdrc-2020-001698 |
| Popis: | IntroductionDistal sensorimotor polyneuropathy (DSPN) is common in people with diabetes but is also found in pre-diabetes. Peripheral nerve myelin damage, which can be assessed by reduced nerve conduction velocity (NCV), is an essential feature of DSPN. Emerging evidence indicates that the development of DSPN may involve the activation of the immune system. However, available studies have mainly investigated circulating immune mediators, whereas the role of immune cells remains unclear. Therefore, we aimed to test whether leukocyte subsets are associated with NCV.Research design and methodsThis cross-sectional study analyzed data from 850 individuals (of whom 252 and 118 had type 2 diabetes and pre-diabetes, respectively) of the Maastricht Study. NCV was measured in the peroneal and tibial motor nerves and the sural sensory nerve and summed to calculate a standardized NCV sum score. Associations between percentages of leukocyte subsets and NCV sum scores were estimated using linear regression models adjusted for demographic, lifestyle, metabolic and clinical covariates.ResultsAfter adjustment for covariates, higher percentages of basophils and CD4+ T cells were associated with lower NCV (p=0.014 and p=0.005, respectively). The percentage of CD8+ T cells was positively associated with NCV (p=0.022). These associations were not modified by glucose metabolism status (all pinteraction >0.05). No associations were found for monocytes, eosinophils, neutrophils, lymphocytes, total T cells, Treg cells and B cells.ConclusionsThe associations of basophils, CD4+ and CD8+ T cells with NCV suggest that cell types from both innate and adaptive immunity may be implicated in the development of DSPN. |
| Databáze: | OpenAIRE |
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