Evaluation of Antioxidant Activity and Histopathological Changes Occurred by the Oral Ingestion of CuO Nanoparticles in Monosodium Urate Crystal-Induced Hyperuricemic BALB/c Mice
| Autor: | Maisra Azhar Butt, Mubin Mustafa Kiyani, Moheen Mustafa, Tariq Mahmood, Abdul Ghafoor Sajjad, Syed Sajid Hussain Shah, Hamza Rehman, Syed Ali Imran Bokhari |
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| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
Thiobarbituric acid Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry 010501 environmental sciences Pharmacology 01 natural sciences Biochemistry Antioxidants BALB/c Inorganic Chemistry Superoxide dismutase Eating Mice 03 medical and health sciences chemistry.chemical_compound Oral administration medicine TBARS Animals Hyperuricemia 0105 earth and related environmental sciences Mice Inbred BALB C 0303 health sciences biology Arthritis Gouty Chemistry 030302 biochemistry & molecular biology Biochemistry (medical) General Medicine medicine.disease biology.organism_classification Uric Acid Gout biology.protein Nanoparticles Copper |
| Zdroj: | Biological Trace Element Research. 200:217-227 |
| ISSN: | 1559-0720 0163-4984 |
| DOI: | 10.1007/s12011-021-02615-3 |
| Popis: | Nanotechnology is an intensive branch of science due to the unique features of nano range particles (1-100 nm). Their nano size results in a high surface area of absorption when orally administered. Monosodium urate crystal excessive deposition causes a commonly known inflammatory disease called gout into the synovial joints. Previously it has been observed that copper oxide nanoparticles (CuONPs) had a significant effect in reducing the serum uric acid levels in BALB/c mice as well as reducing the inflammation in the ankles of mice. This study was made to investigate the antioxidant and histopathological changes in hyperuricemic BALB/c mice upon the oral administration of copper oxide nanoparticles. Different concentrations of copper oxide nanoparticles 5, 10, and 20 ppm were given orally to gouty mice. To investigate the antioxidant activity of CuONPs, various antioxidant protocols were applied. It was noted that the nanoparticle-treated group of 20 ppm showed no significant changes in superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), thiobarbituric acid reactive substances (TBARS), and ROS values while the protein estimation values of the negative control group exhibited a significant increase (0.001). When compared to negative control, no significant effect was shown on the interpretation of histopathological changes of muscles, kidney, and liver tissues. |
| Databáze: | OpenAIRE |
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