Advances in the study of CDC42 in the female reproductive system
Autor: | Wenpei Xiang, Xiaofei Wang, Huiying Li, Yu Liu, Qiaojuan Mei |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
rho GTP-Binding Proteins
Reviews CDC42 Review Biology medicine meiosis Animals Reproductive system Rho‐GTPase oocyte cdc42 GTP-Binding Protein Gametogenesis reproductive system Translation (biology) Cell Biology Genitalia Female Membrane transport Oocyte Actins Cell biology Actin Cytoskeleton medicine.anatomical_structure Signalling Oocytes Molecular Medicine Female Cytokinesis |
Zdroj: | Journal of Cellular and Molecular Medicine |
ISSN: | 1582-4934 1582-1838 |
Popis: | CDC42 is a member of the Rho‐GTPase family and is involved in a variety of cellular functions including regulation of cell cycle progression, constitution of the actin backbone and membrane transport. In particular, CDC42 plays a key role in the establishment of polarity in female vertebrate oocytes, and essential to this major regulatory role is its local occupation of specific regions of the cell to ensure that the contractile ring is assembled at the right time and place to ensure proper gametogenesis. The multifactor controlled ‘inactivation‐activation’ process of CDC42 also allows it to play an important role in the multilevel signalling network, and the synergistic regulation of multiple genes ensures maximum precision during gametogenesis. The purpose of this paper is to review the role of CDC42 in the control of gametogenesis and to explore its related mechanisms, with the aim of further understanding the great research potential of CDC42 in female vertebrate germ cells and its future clinical translation. |
Databáze: | OpenAIRE |
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