Cu(OTf)2-catalyzed synthesis of highly substituted 1-methoxy imidazoles via (3 + 2) cycloaddition between imino carbenoids and nitriles

Autor:	Lourdusamy Emmanuvel, Samuel Vasanthkumar, Bharath Kumar Kuruba
Rok vydání:	2016
Předmět:	chemistry.chemical_classification 010405 organic chemistry Aryl Organic Chemistry Substrate (chemistry) 010402 general chemistry 01 natural sciences Medicinal chemistry Cycloaddition 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Organic chemistry Imidazole Alkyl
DOI:	10.6084/m9.figshare.3181324.v2
Popis:	A Cu(OTf)2-catalyzed simple synthetic approach for highly substituted 1-alkoxy imidazole has been described. This protocol involves (3 + 2) cycloaddition of oximino carbenoids with organo nitriles. This method has wide substrate scope and tolerates alkyl, aryl, substituted aryl, vinyl, and ester nitriles.
Databáze:	OpenAIRE
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