123I-FP-CIT SPECT Imaging of Dopamine Transporters in Patients with Recurrent Sudden Falls: Are Such Falls a Distinct Entity?
| Autor: | Ilan Ziv, T. A. Treves, Mordechai Lorberboym, Ruth Djaldetti, Eldad Melamed |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Pathology medicine.medical_specialty Central nervous system Poison control Iodine Radioisotopes Parkinsonian Disorders 123I-FP-CIT Dopamine Spect imaging Internal medicine Basal ganglia medicine Humans Radiology Nuclear Medicine and imaging In patient Aged Aged 80 and over Tomography Emission-Computed Single-Photon Dopamine Plasma Membrane Transport Proteins Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Dementia Vascular Magnetic resonance imaging General Medicine Multiple System Atrophy Magnetic Resonance Imaging Corpus Striatum medicine.anatomical_structure nervous system Cardiology Accidental Falls Female Supranuclear Palsy Progressive Radiopharmaceuticals business Tropanes medicine.drug |
| Zdroj: | Journal of Nuclear Medicine Technology. 35:232-236 |
| ISSN: | 0091-4916 |
| DOI: | 10.2967/jnmt.107.040238 |
| Popis: | Recurrent falls in older people are commonly associated with abnormalities that involve several parts of the central nervous system, especially with basal ganglion pathology. The aim of the present study was to evaluate the integrity of striatal dopamine transporters (DaTs) by use of 123I-N-3-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)tropane (123I-FP-CIT) SPECT of striatal DaTs in patients with recurrent sudden falls. Methods: Twenty-one patients without a definite neurologic diagnosis for recurrent sudden falls were enrolled in a cross-sectional study. SPECT with a DaT ligand was performed 180 min after injection of 185 MBq of 123I-FP-CIT with a dual-head γ-camera. Results: DaT SPECT findings were normal in 15 of 21 patients (71%). Of those, 73% had abnormal MRI findings suggestive of atherosclerotic lesions. Eleven patients with normal DaT SPECT findings had mild parkinsonian symptoms. There was no correlation of the SPECT results with patient age, duration of occurrence of falls, or frequency of falls, and there was no significant difference in the relative distributions of SPECT findings between patients with and patients without parkinsonian symptoms or vascular risk factors. Conclusion: Recurrent sudden falls are, in most cases, not attributable to the degeneration of the nigrostriatal system. |
| Databáze: | OpenAIRE |
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