Studies of glycine oxidation in rat tissues

Autor:	Henry I. Nakada, Sidney Weinhouse
Rok vydání:	1953
Předmět:	chemistry.chemical_classification biology Biochemical Phenomena Glycine Biophysics Glyoxylate cycle Kidney Biochemistry Oxalate Rats Amino acid chemistry.chemical_compound Enzyme Liver chemistry Xanthine dehydrogenase Catalase biology.protein Animals Formate Oxidation-Reduction Molecular Biology
Zdroj:	Archives of Biochemistry and Biophysics. 42:257-270
ISSN:	0003-9861
DOI:	10.1016/0003-9861(53)90356-7
Popis:	Using labeled substrates in vitro the oxidation of glycine α- and β-carbons was observed in rat liver and kidney but not in other organs. Glyoxylate α-carbon and formate were identified as intermediates of the oxidation of the glycine α-carbon. The interconversion of glyoxylate and glycolate occurs readily in liver and is catalyzed by DPN-specific lactic dehydrogenase. Glyoxylate was found to be oxidized by xanthine dehydrogenase to oxalate, and to formate and CO 2 by an as yet uncharacterized enzyme in rat liver. Formate is oxidized readily by a variety of rat tissues, and evidence has been presented to indicate this occurs via a peroxidative activity of catalase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acc05157b58ab36f6b24983b8425ea0 https://doi.org/10.1016/0003-9861(53)90356-7 Zobrazit plný text záznamu