| Autor: |
Lauren C. Shuffrey, Morgan R. Firestein, Margaret H. Kyle, Andrea Fields, Carmela Alcántara, Dima Amso, Judy Austin, Jennifer M. Bain, Jennifer Barbosa, Mary Bence, Catherine Bianco, Cristina R. Fernández, Sylvie Goldman, Cynthia Gyamfi-Bannerman, Violet Hott, Yunzhe Hu, Maha Hussain, Pam Factor-Litvak, Maristella Lucchini, Arthur Mandel, Rachel Marsh, Danielle McBrian, Mirella Mourad, Rebecca Muhle, Kimberly G. Noble, Anna A. Penn, Cynthia Rodriguez, Ayesha Sania, Wendy G. Silver, Kally C. O’Reilly, Melissa Stockwell, Nim Tottenham, Martha G. Welch, Noelia Zork, William P. Fifer, Catherine Monk, Dani Dumitriu |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
JAMA Pediatr |
| Popis: |
IMPORTANCE: Associations between in utero exposure to maternal SARS-CoV-2 infection and neurodevelopment are speculated, but currently unknown. OBJECTIVE: To examine the associations between maternal SARS-CoV-2 infection during pregnancy, being born during the COVID-19 pandemic regardless of maternal SARS-CoV-2 status, and neurodevelopment at age 6 months. DESIGN, SETTING, AND PARTICIPANTS: A cohort of infants exposed to maternal SARS-CoV-2 infection during pregnancy and unexposed controls was enrolled in the COVID-19 Mother Baby Outcomes Initiative at Columbia University Irving Medical Center in New York City. All women who delivered at Columbia University Irving Medical Center with a SARS-CoV-2 infection during pregnancy were approached. Women with unexposed infants were approached based on similar gestational age at birth, date of birth, sex, and mode of delivery. Neurodevelopment was assessed using the Ages & Stages Questionnaire, 3rd Edition (ASQ-3) at age 6 months. A historical cohort of infants born before the pandemic who had completed the 6-month ASQ-3 were included in secondary analyses. EXPOSURES: Maternal SARS-CoV-2 infection during pregnancy and birth during the COVID-19 pandemic. MAIN OUTCOMES AND MEASURES: Outcomes were scores on the 5 ASQ-3 subdomains, with the hypothesis that maternal SARS-CoV-2 infection during pregnancy would be associated with decrements in social and motor development at age 6 months. RESULTS: Of 1706 women approached, 596 enrolled; 385 women were invited to a 6-month assessment, of whom 272 (70.6%) completed the ASQ-3. Data were available for 255 infants enrolled in the COVID-19 Mother Baby Outcomes Initiative (114 in utero exposed, 141 unexposed to SARS-CoV-2; median maternal age at delivery, 32.0 [IQR, 19.0-45.0] years). Data were also available from a historical cohort of 62 infants born before the pandemic. In utero exposure to maternal SARS-CoV-2 infection was not associated with significant differences on any ASQ-3 subdomain, regardless of infection timing or severity. However, compared with the historical cohort, infants born during the pandemic had significantly lower scores on gross motor (mean difference, −5.63; 95% CI, −8.75 to −2.51; F(1,267) = 12.63; P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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