The impact of brain‐derived neurotrophic factor Val66Met polymorphism on cognition and functional brain networks in patients with intractable partial epilepsy

Autor: Marina Perona, Jane L. Burdett, Alexandra Foulkes, Silvia B. Bonelli, Meneka K. Sidhu, Jason Stretton, John S. Duncan, E. Williams, Maria Thom, Britta Wandschneider, Jane de Tisi, Mar Matarin, Pamela J. Thompson
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Adult
Male
Drug Resistant Epilepsy
Genotype
Neuropsychological Tests
Hippocampus
Neurosurgical Procedures
Temporal lobe
03 medical and health sciences
Epilepsy
0302 clinical medicine
Gene Frequency
Memory
Physiology (medical)
Medicine
Memory impairment
Humans
Pharmacology (medical)
Cognitive Dysfunction
Effects of sleep deprivation on cognitive performance
Cognitive decline
Default mode network
Pharmacology
Brain-derived neurotrophic factor
Polymorphism
Genetic
business.industry
Brain-Derived Neurotrophic Factor
Cognition
Original Articles
medicine.disease
Magnetic Resonance Imaging
nervous system diseases
Psychiatry and Mental health
030104 developmental biology
England
Epilepsy
Temporal Lobe
Female
Epilepsies
Partial
Nerve Net
business
Neuroscience
030217 neurology & neurosurgery
Psychomotor Performance
Popis: Introduction Medial temporal lobe epilepsy (mTLE) is the most common refractory focal epilepsy in adults. Around 30%-40% of patients have prominent memory impairment and experience significant postoperative memory and language decline after surgical treatment. BDNF Val66Met polymorphism has also been associated with cognition and variability in structural and functional hippocampal indices in healthy controls and some patient groups. Aims We examined whether BDNF Val66Met variation was associated with cognitive impairment in mTLE. Methods In this study, we investigated the association of Val66Met polymorphism with cognitive performance (n = 276), postoperative cognitive change (n = 126) and fMRI activation patterns during memory encoding and language paradigms in 2 groups of patients with mTLE (n = 37 and 34). Results mTLE patients carrying the Met allele performed more poorly on memory tasks and showed reduced medial temporal lobe activation and reduced task-related deactivations within the default mode networks in both the fMRI memory and language tasks than Val/Val patients. Conclusions Although cognitive impairment in epilepsy is the result of a complex interaction of factors, our results suggest a role of genetic factors on cognitive impairment in mTLE.
Databáze: OpenAIRE
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