Kidney Biopsy in Type 2 Diabetes: A Multicenter Cross-Sectional Study
| Autor: | Laurent Daniel, François Vrtovsnik, Jonathan Maurice Chemouny, Elsa Ferriere, Cécile Vigneau, Jean-Michel Halimi, Noémie Jourde-Chiche, Valentin Maisons, Christophe Barba, Nathalie Rioux-Leclercq, Dominique Joly, Aurélie Sannier, Mickaël Bobot |
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| Přispěvatelé: | Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Necker - Enfants Malades [AP-HP], CHU Pontchaillou [Rennes], Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Time Factors [SDV]Life Sciences [q-bio] Biopsy Kidney biopsy 030232 urology & nephrology Renal function Diabetic nephropathy Type 2 diabetes 030204 cardiovascular system & hematology Kidney Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Hypertensive Nephropathy medicine Humans Diabetic kidney disease Aged Hematuria Retrospective Studies Proteinuria business.industry Patient Selection Middle Aged medicine.disease 3. Good health Hypertensive kidney disease Cross-Sectional Studies Diabetes Mellitus Type 2 Nephrology Female Kidney Diseases medicine.symptom business Nephrotic syndrome Glomerular Filtration Rate |
| Zdroj: | American Journal of Nephrology American Journal of Nephrology, Karger, 2021, 52 (2), pp.131-140. ⟨10.1159/000514259⟩ American Journal of Nephrology, 2021, 52 (2), pp.131-140. ⟨10.1159/000514259⟩ |
| ISSN: | 1421-9670 0250-8095 |
| Popis: | Introduction: Kidney biopsies (KBs) are performed in patients with type 2 diabetes (T2D) to diagnose non-diabetic or hypertensive kidney disease (NDHKD) potentially requiring specific management compared to diabetic and or hypertensive nephropathy (absence of NDHKD). Indications for KB are based on the presence of atypical features compared to the typical course of diabetic nephropathy. In this study, we assessed the association of different patterns of atypical features, or KB indications, with NDHKD. Methods: Native KBs performed in patients with T2D were analyzed. Data were collected from the patients’ records. KB indications were determined according to the presence of different atypical features considered sequentially: (1) presence of any feature suggesting NDHKD which is not among the following ones, (2) recent onset of nephrotic syndrome, (3) low or rapidly declining estimated glomerular filtration rate (eGFR), (4) rapid increase in proteinuria, (5) short duration of diabetes, (6) presence of hematuria, or (7) normal retinal examination. Results: Among the 463 KBs analyzed, NDHKD was diagnosed in 40% of the total population and 54, 40, 24, and 7% of the KBs performed for indications 1–4 respectively. Conversely, no patient who underwent KB for indications 5–7 displayed NDHKD. Logistic regression analyses identified eGFRCKD-EPI >15 mL/min/1.73 m2, urinary protein-to-Cr ratio |
| Databáze: | OpenAIRE |
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