Cerebral Metabolic Responses to Clomipramine Are Greatly Reduced Following Pretreatment with the Specific Serotonin Neurotoxin Para-Chloroamphetamine (PCA)
| Autor: | Ulderico Freo, Pietro Pietrini, Leontino Battistin, Antonio Merico, S. Ruggero, Mauro Dam, Gilberto Pizzolato, Maura L. Furey |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pharmacology
Clomipramine medicine.medical_specialty business.industry para-Chloroamphetamine Hippocampus chemistry.chemical_compound Psychiatry and Mental health Endocrinology chemistry Internal medicine Anesthesia medicine Antidepressant Serotonin Reuptake inhibitor P-Chloroamphetamine business Raphe nuclei medicine.drug |
| Zdroj: | Neuropsychopharmacology. 13:215-222 |
| ISSN: | 0893-133X |
| DOI: | 10.1038/sj.npp.1380285 |
| Popis: | To determine if reported reductions of regional cerebral metabolic rates for glucose (rCMRglc) induced by the tryciclic antidepressant clomipramine (CMI) (10 mg/kg) are due to a presynaptic action on serotonin (5-HT) terminals, 3-month-old Fischer-344 rats were given parachloroamphetamine (PCA), a serotonin neurotoxin. rCMRglc was measured 3 weeks later in 55 brain regions after the administration of saline or CMI using the quantitative autoradiographic [14C]2-deoxyglucose procedure. PCA alone increased rCMRglc in the visual cortex. CMI alone reduced rCMRglc in 18 (33%) of the studied regions, including telencephalic, diencephalic, limbic, and brain stem areas. In PCA-lesioned rats, metabolic responses to CMI (10 mg/kg) were greatly reduced, and significant rCMRglc decreases were observed only in 4 (7%) of the brain areas, including the hippocampus and raphe nuclei. Abolition by PCA of the metabolic responses to CMI confirms that CMI, at the dose studied, reduces rCMRglc via a presynaptic mechanism, likely the 5-HT reuptake sites. |
| Databáze: | OpenAIRE |
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