Rapid screening of COVID‐19 patients using white blood cell scattergrams, a study on 381 patients

Autor: Victoria Raggueneau, François Mignon, Ernesto Diaz-Flores, Claire Flaujac, Mehrsa Koukabi, Marie Temple, Philippe Rousselot, Benjamin Manéglier, Jennifer Osman, Fabrice Bruneel, Floriane Devaux, Alix Greder-Belan, Stéphanie Marque-Juillet, Rémy Favre, Jérôme Lambert, Reza Azarian, Véronique Hentgen, Delphine Bridoux
Přispěvatelé: Centre Hospitalier de Versailles André Mignot (CHV), Institute of Medical Biometry and Statistics [Fribourg] (IMBI), Faculty of Medicine and Medical Center, University of Fribourg-University of Fribourg, UCSF Benioff Children's Hospital Oakland, University of California [San Francisco] (UCSF), University of California-University of California, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), None reported.
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
Adolescent
Coronavirus disease 2019 (COVID-19)
[SDV]Life Sciences [q-bio]
Pneumonia
Viral
Short Report
coronavirus
Chest ct
white blood cells scattergram
Computed tomography
Betacoronavirus
03 medical and health sciences
0302 clinical medicine
Short Reports
COVID‐19
Plasmacytoid Lymphocytes
White blood cell
Humans
Mass Screening
Medicine
Lymphocyte Count
Lymphocytes
Pandemics
Mass screening
Aged
Aged
80 and over
medicine.diagnostic_test
Reverse Transcriptase Polymerase Chain Reaction
SARS-CoV-2
business.industry
COVID-19
Hematology
Middle Aged
Predictive value
SARS‐Cov‐2
Reverse transcriptase
3. Good health
medicine.anatomical_structure
030220 oncology & carcinogenesis
plasmacytoid lymphocytes
Female
Radiology
Coronavirus Infections
Tomography
X-Ray Computed
business
030215 immunology
Zdroj: British Journal of Haematology
British Journal of Haematology, Wiley, 2020, 190 (5), pp.718-722. ⟨10.1111/bjh.16943⟩
ISSN: 1365-2141
0007-1048
DOI: 10.1111/bjh.16943
Popis: International audience; Complementary tools are warranted to increase the sensitivity of the initial testing for COVID-19. We identified a specific ‘sandglass’ aspect on the white blood cell scattergram of COVID-19 patients reflecting the presence of circulating plasmacytoid lymphocytes. Patients were dichotomized as COVID-19-positive or -negative based on reverse transcriptase polymerase chain reaction (RT-PCR) and chest computed tomography (CT) scan results. Sensitivity and specificity of the ‘sandglass’ aspect were 85·9% and 83·5% respectively. The positive predictive value was 94·3%. Our findings provide a non-invasive and simple tool to quickly categorize symptomatic patients as either COVID-19-probable or -improbable especially when RT-PCR and/or chest CT are not rapidly available.
Databáze: OpenAIRE
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