Long-Term Results of Intracardiac Mesenchymal Stem Cell Transplantation in Patients With Cardiomyopathy
| Autor: | Soichiro Kitamura, Hisao Ogawa, Toshihisa Anzai, Hajime Ohgushi, Noritoshi Nagaya, Teruo Noguchi, Wataru Shimizu, Kazuhiro Satomi, Takeshi Yagyu, Takeshi Nakatani, Satoshi Yasuda, Kenji Kangawa, Kaori Doi, Kengo Kusano |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Cardiac Catheterization medicine.medical_treatment Cardiomyopathy 030204 cardiovascular system & hematology Mesenchymal Stem Cell Transplantation Intracardiac injection Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Japan Internal medicine medicine Humans 030212 general & internal medicine Prospective Studies Adverse effect Heart transplantation Heart Failure Ischemic cardiomyopathy Ejection fraction business.industry General Medicine Middle Aged medicine.disease Transplantation Survival Rate Heart failure Cardiology Female Cardiology and Cardiovascular Medicine business Cardiomyopathies Follow-Up Studies |
| Zdroj: | Circulation journal : official journal of the Japanese Circulation Society. 83(7) |
| ISSN: | 1347-4820 |
| Popis: | Background Mesenchymal stem cells (MSCs), which have the potential to differentiate into cardiomyocytes or vascular endothelial cells, have been used clinically as therapy for cardiomyopathy. In this study, we aimed to evaluate the long-term follow-up results.Methods and Results:We studied 8 patients with symptomatic heart failure (HF) on guideline-directed therapy (ischemic cardiomyopathy, n=3; nonischemic cardiomyopathy, n=5) who underwent intracardiac MSC transplantation using a catheter-based injection method between May 2004 and April 2006. Major adverse events and hospitalizations were investigated up to 10 years afterward. Compared with baseline, there were no significant differences in B-type natriuretic peptide (BNP) (from 211 to 173 pg/mL), left ventricular ejection fraction (LVEF) (from 24% to 26%), and peak oxygen uptake (from 16.5 to 19.2 mL/min/kg) at 2 months. During the follow-up period, no patients experienced serious adverse events such as arrhythmias. Three patients died of pneumonia in the 1st year, liver cancer in the 6th year, and HF in the 7th year. Of the remaining 5 patients, 3 patients were hospitalized for exacerbated HF, 1 of whom required heart transplantation in the 2nd year; 2 patients survived for 10 years without worsening HF. Conclusions The results of this exploratory study of intracardiac MSCs administration suggest further research regarding the feasibility and efficacy is warranted. |
| Databáze: | OpenAIRE |
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