Common STAT3 variants are not associated with obesity or insulin resistance in female twins
| Autor: | Sandra D. O'Dell, Xiaoling Wang, Tim D. Spector, Carl A. Lane, Theodosios Kyriakou, Sakina B. Gooljar, Laura J. Collins, Yalda Jamshidi, Harold Snieder |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
STAT3 Transcription Factor medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Population POWER Medicine (miscellaneous) Single-nucleotide polymorphism Polymorphism Single Nucleotide Article Endocrinology Insulin resistance Internal medicine insulin resistance Genetic predisposition LINKAGE Medicine Glucose homeostasis Humans Obesity education education.field_of_study Nutrition and Dietetics business.industry Insulin Genetic Variation Middle Aged medicine.disease United Kingdom Minor allele frequency MICE fat distribution Female business signal transduction genetic susceptibility |
| Zdroj: | Obesity, 15(7), 1634-1639. Wiley-Blackwell |
| ISSN: | 1930-7381 |
| Popis: | JAMSHIDI, YALDA, THEODOSIOS KYRIAKOU, SAKINA B. GOOLJAR, LAURA J. COLLINS, CARL A. LANE, HAROLD SNIEDER, XIAOLING WANG, TIM D. SPECTOR, AND SANDRA D. O'DELL. Common STAT3 variants are not associated with obesity or insulin resistance in female twins. Obesity. 2007; 15:1634-1639. In animal models, STAT3 action in the hypothalamus and liver appears essential for normal body weight and glucose homeostasis in response to insulin. We hypothesized that variation in the STAT3 gene may be associated with body fat and/or insulin resistance in the general population. Five tagging SNPs spanning the STAT3 gene, rs8074524, rs2293152, rs2306580, rs6503695, and rs7211777 were genotyped in 2776 white female twins (mean age, 47.4 +/- 12.5 yrs) from the St Thomas' United Kingdom Adult Twin Registry (Twins UK). Minor allele frequencies were as follows: rs8074524 (0.19), rs2293152 (0.37), rs2306580 (0.06), rs6503695 (0.35), and rs7211777 (0.34). The minor allele of rs2293152 was associated with higher homeostasis model assessment index of insulin resistance (p = 0.013) in the full cohort and confirmed in sib-transmission/disequilibrium test (TDT): (p = 0.015; n = 60). However, there were no associations with fasting serum insulin or glucose or with obesity variables. Although defective STAT3 action results in obesity and insulin resistance in animal models, we failed to establish any indicative associations with common SNPs in this human study. |
| Databáze: | OpenAIRE |
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