Treatment in carbon monoxide poisoning patients with headache: a prospective, multicenter, double-blind, controlled clinical trial

Autor: Mustafa Basturk, Mustafa Serinken, Arif Duran, Erdal Tekin, Mucahit Emet, Tarik Ocak
Rok vydání: 2016
Předmět:
Male
double blind procedure
Metoclopramide
Dipyrone
Poison control
oxygen therapy
Turkey (republic)
law.invention
chemistry.chemical_compound
0302 clinical medicine
Randomized controlled trial
law
middle aged
carboxyhemoglobin
Adult
Analgesics/*therapeutic use
Carbon Monoxide Poisoning/blood/complications/*therapy
Carboxyhemoglobin/metabolism
Combined Modality Therapy
Dipyrone/*therapeutic use
Dopamine D2 Receptor Antagonists/*therapeutic use
Double-Blind Method
Female
Headache/*drug therapy/etiology
Humans
Metoclopramide/*therapeutic use
Middle Aged
Nausea/etiology
Oxygen Inhalation Therapy
Pain Measurement
Prospective Studies
Young Adult
multimodality cancer therapy
Analgesics
education.field_of_study
Carbon monoxide poisoning
adult
Headache
clinical trial
Nausea
analgesic agent
General Medicine
Metamizole
Dopamine D2 Receptor Antagonists
female
priority journal
Anesthesia
Emergency Medicine
young adult
medicine.symptom
metoclopramide
prospective study
medicine.drug
Population
complication
Article
Carbon Monoxide Poisoning
03 medical and health sciences
carbon monoxide intoxication
blood
medicine
controlled study
human
education
business.industry
visual analog scale
030208 emergency & critical care medicine
medicine.disease
drug efficacy
multicenter study
chemistry
randomized controlled trial
Carboxyhemoglobin
dopamine 2 receptor blocking agent
business
oxygen
metabolism
030217 neurology & neurosurgery
Zdroj: The American Journal of Emergency Medicine. 34:2140-2145
ISSN: 0735-6757
DOI: 10.1016/j.ajem.2016.08.002
Popis: Background There is a lack of specificity of the analgesic agents used to treat headache and underlying acute carbon monoxide poisoning. Objective To compare effectiveness of “oxygen alone” vs “metoclopramide plus oxygen” vs “metamizole plus oxygen” therapy in treating carbon monoxide–induced headache. Design A prospective, multicenter, double-blind, controlled trial. Setting Three emergency departments in Turkey. Population Adult carbon monoxide poisoning patients with headache. Methods A total of 117 carbon monoxide-intoxicated patients with headache were randomized into 3 groups and assessed at baseline, 30 minutes, 90 minutes, and 4 hours. Main Outcome Measure The primary outcome was patient-reported improvement rates for headache. Secondary end points included nausea, need for rescue medication during treatment, and reduction in carboxyhemoglobin levels. Results During observation, there was no statistical difference between drug type and visual analog scale score change at 30 minutes, 90 minutes, or 4 hours, for either headache or nausea. No rescue medication was needed during the study period. The reduction in carboxyhemoglobin levels did not differ among the 3 groups. Conclusion The use of “oxygen alone” is as efficacious as “oxygen plus metoclopramide” or “oxygen plus metamizole sodium” in the treatment of carbon monoxide–induced headache.
Databáze: OpenAIRE
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