The Occurrence of Antibodies Against Gluten in Children with Autism Spectrum Disorders Does Not Correlate with Serological Markers of Impaired Intestinal Permeability
| Autor: | Ewa Konopka, Paweł Józefczuk, Weronika Surdy, Lucjan Sobol, Jan Józefczuk, Joanna Bierła, Agnieszka Sowińska, Ilona Trojanowska, Bożena Cukrowska, Rafał Czarnecki |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Cholera Toxin Adolescent Glutens Tissue transglutaminase Autism Spectrum Disorder Medicine (miscellaneous) Biology Fatty Acid-Binding Proteins Antibodies Permeability Serology 03 medical and health sciences 0302 clinical medicine mental disorders medicine Humans Intestinal Mucosa Protein Precursors Child chemistry.chemical_classification Nutrition and Dietetics Intestinal permeability Haptoglobins Zonulin medicine.disease Gluten chemistry Child Preschool Immunology Anti-gliadin antibodies biology.protein Autism 030211 gastroenterology & hepatology Female Antibody 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Journal of medicinal food. 21(2) |
| ISSN: | 1557-7600 |
| Popis: | There is evidence that children with autism spectrum disorders (ASDs) display an increased immune reactivity against gluten, which is supposed to be the effect of intestinal barrier abnormalities. The aim of study was to evaluate the relation of antibody induced by gluten to zonulin and intestinal fatty acid binding proteins (I-FABP), that is, serological markers of an impaired gut barrier. The study included 77 patients with ASDs. Zonulin, I-FABP, celiac-specific antibodies, anti-gliadin antibodies (AGA), and antibodies against neural transglutaminase 6 (TG6) of immunoglobulin (Ig) A and IgG classes were detected in sera. Celiac-specific antibodies were negative in all ASD children, four children (5.2%) had positive anti-TG6 antibodies, and increased AGA-IgG production was found in 21 patients (27.3%). Mean levels of zonulin and I-FABP in ASD patients were similar to those found in healthy controls and revealed a negative correlation with age, whereas regression analysis revealed a significant positive relationship between antibody production and the age. Serum concentrations of zonulin and I-FABP showed no statistically significant association with antibody positivity. An increased production of antibodies related to gliadin and neural TG6 in ASD children is not related to serological markers of an impaired intestinal barrier. |
| Databáze: | OpenAIRE |
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