Effect of efavirenz on the pharmacokinetics of ketoconazole in HIV-infected patients
| Autor: | Werawath Mahatthanatrakul, Somchai Sriwiriyajan, Sutep Jaruratanasirikul, Wibool Ridtitid |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Cyclopropanes Male Antifungal Agents Efavirenz Anti-HIV Agents HIV Infections Pharmacology Biology chemistry.chemical_compound Pharmacokinetics Candidiasis Oral immune system diseases parasitic diseases medicine Humans Drug Interactions heterocyclic compounds Pharmacology (medical) Sida AIDS-Related Opportunistic Infections Reverse-transcriptase inhibitor Stavudine virus diseases Lamivudine General Medicine Middle Aged biochemical phenomena metabolism and nutrition Drug interaction biology.organism_classification Benzoxazines Ketoconazole chemistry Alkynes Area Under Curve Female Half-Life medicine.drug |
| Zdroj: | European Journal of Clinical Pharmacology. 63:479-483 |
| ISSN: | 1432-1041 0031-6970 |
| Popis: | To investigate the effect of efavirenz on the ketoconazole pharmacokinetics in HIV-infected patients.Twelve HIV-infected patients were assigned into a one-sequence, two-period pharmacokinetic interaction study. In phase one, the patients received 400 mg of ketoconazole as a single oral dose on day 1; in phase two, they received 600 mg of efavirenz once daily in combination with 150 mg of lamivudine and 30 or 40 mg of stavudine twice daily on days 2 to 16. On day 16, 400 mg of ketoconazole was added to the regimen as a single oral dose. Ketoconazole pharmacokinetics were studied on days 1 and 16.Pretreatment with efavirenz significantly increased the clearance of ketoconazole by 201%. C(max) and AUC(0-24) were significantly decreased by 44 and 72%, respectively. The T ((1/2)) was significantly shorter by 58%.Efavirenz has a strong inducing effect on the metabolism of ketoconazole. |
| Databáze: | OpenAIRE |
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