H19 gene polymorphisms and neuroblastoma susceptibility in Chinese children: a six-center case-control study
| Autor: | Yong Li, Zhen-Jian Zhuo, Haiyan Zhou, Jiabin Liu, Jiao Zhang, Jiwen Cheng, Haixia Zhou, Suhong Li, Ming Li, Jun He, Zhenghui Xiao, Jing He, Yaling Xiao |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Single-nucleotide polymorphism Biology susceptibility polymorphism 03 medical and health sciences neuroblastoma 0302 clinical medicine lncRNA Polymorphism (computer science) Neuroblastoma Internal medicine Genotype medicine Gene H19 Case-control study Cancer Odds ratio medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| Popis: | Neuroblastoma is one of the most common life-threatening extracranial tumors that mainly occurs in children, and its genetic etiology remains largely obscure. RNA m6A modification has been thought to play a key role in cancer progression. YTHDF1 is the critical downstream gene by which RNA m6A modification exerts its functions. Single nucleotide polymorphisms in the YTHDF1 gene may affect its expression and biological activity, thereby leading to abnormalities in the regulation of downstream m6A-modified RNA and eventually promoting the initiation and development of tumors. Here, we attempted to evaluate the contributions of two polymorphisms (rs6011668 C>T and rs6090311 A>G) in the YTHDF1 gene to neuroblastoma susceptibility in 898 cases and 1734 controls that originated in China. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in the logistic regression models to evaluate the associations between selected polymorphisms and neuroblastoma risk. Overall, either in a single locus or combination analysis, no significant association with neuroblastoma risk was found for either of the two selected polymorphisms. However, the stratified analysis showed that rs6090311AG/GG genotypes significantly reduced the neuroblastoma risk in males (adjusted OR=0.77, 95% CI=0.62-0.96, P=0.018). Moreover, we found that subjects with 2 protective genotypes had a lower tumor risk in males than in those with 0-1 protective genotypes (adjusted OR=0.77, 95% CI=0.62-0.96, P=0.018). In summary, our study indicates that YTHDF1 gene polymorphisms may weakly contribute to neuroblastoma susceptibility. Our findings should be further verified by well-designed studies with larger sample sizes. |
| Databáze: | OpenAIRE |
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