Exploring the Molecular Pathways Behind the Effects of Nutrients and Dietary Polyphenols on Gut Microbiota and Intestinal Permeability: A Perspective on the Potential of Metabolomics and Future Clinical Applications
| Autor: | Paul A. Kroon, Benjamin Kirkup, Mar Garcia-Aloy, Cristina Andres-Lacueva, Raúl González-Domínguez, Simone Guglielmetti, Gregorio Peron, Nicole Hidalgo-Liberona, Stefano Bernardi, Antonio Cherubini, Patrizia Riso |
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| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Aging Microbiologia Microbiota intestinal Gut flora Bioinformatics 01 natural sciences digestive system Microbiology Permeability aging gut microbiota intestinal permeability metabolomics nutrients polyphenols Animals Humans Intestinal Mucosa Metabolomics Nutrients Polyphenols Gastrointestinal Microbiome Envelliment Gastrointestinal mucosa medicine Gastrointestinal microbiome Intestinal permeability biology 010401 analytical chemistry Mucosa gastrointestinal General Chemistry biology.organism_classification medicine.disease Metabolisme 0104 chemical sciences Metabolism Metabolòmica Polifenols General Agricultural and Biological Sciences Older people 010606 plant biology & botany |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | The gut microbiota is involved in the regulation of the intestinal permeability (IP), whose disruption is a frequent condition in older people and is associated with the development of several diseases. The diet can affect the gut microbiota and IP, although the molecular mechanisms involved are unclear. Metabolomics is one of the suitable approaches to study the effects of diet on gut microbiota and IP, although, up to now, the research has focused only on a few dietary components. The aim here was to review the most recent literature concerning the application of metabolomics to the study of the diet-induced alterations of gut microbiota and the effects on IP, with a particular focus on the molecular pathways involved. An additional aim was to give a perspective on the future research involving dietary polyphenols, because despite their potential use in the management of increased IP, few studies have been reported to date. |
| Databáze: | OpenAIRE |
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