Topiramate Blood Levels During Polytherapy for Epilepsy in Children
| Autor: | Taira Toki, Masahiro Ishii, Toshiyuki Iwasaki |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Topiramate Adolescent Dose Metabolic Clearance Rate 03 medical and health sciences Epilepsy 0302 clinical medicine Seizures Humans Medicine Drug Interactions Pharmacology (medical) Prospective Studies Child Prospective cohort study Pharmacology business.industry Valproic Acid Infant General Medicine medicine.disease Treatment Outcome Epilepsy in children Child Preschool 030220 oncology & carcinogenesis Concomitant Anesthesia Anticonvulsants Drug Therapy Combination Female Epileptic seizure medicine.symptom business 030217 neurology & neurosurgery Follow-Up Studies Blood sampling medicine.drug |
| Zdroj: | American Journal of Therapeutics. 26:e18-e24 |
| ISSN: | 1075-2765 |
| Popis: | BACKGROUND The therapeutic range of topiramate (TPM) blood level is not set because the efficacy and safety are not considered to be related to the level. However, the therapeutic target without side effects is necessary, so the optimal range of TPM blood level was analyzed in this study. STUDY QUESTION This study was conducted to evaluate the efficacy of TPM over 2 years and the utility of measuring blood levels of TPM during the follow-up of epileptic patients. STUDY DESIGN Thirty patients (18 males, 12 females; age range, 6 months-15 years) were treated with TPM for epilepsy. The initial dosage of TPM was 1-3 mg·kg·d. If the effect proved insufficient after 2 weeks, the dosage was increased to 4-9 mg·kg·d. MEASURES AND OUTCOMES Blood levels of TPM were measured by liquid chromatography-tandem mass spectrometry at 1, 6, 12, and 24 months after levels reached steady state. The efficacy of TPM was evaluated by the reduction in epileptic seizure rate (RR) at the time of blood sampling. Statistical analysis was performed using the Mann-Whitney U test. RESULTS A positive correlation was seen between blood levels and maintenance dosages, but no correlation was observed between blood levels and RR. Any significant difference was not identified in TPM levels between the effective group (RR ≥50%) and the ineffective group (RR |
| Databáze: | OpenAIRE |
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