Q fever in the Southern California desert: epidemiology, clinical presentation and treatment
| Autor: | David Brooks, James R. Deforge, Noel Curry, Lawrence A. Cone, Phillip Shaver, Barbara E. Potts |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Q fever California Anti-Infective Agents Virology Internal medicine Epidemiology Trimethoprim Sulfamethoxazole Drug Combination Medicine Endocarditis Animals Humans Natural reservoir Aged Sheep biology business.industry Middle Aged Tetracycline medicine.disease Coxiella burnetii biology.organism_classification Antibodies Bacterial Surgery Infectious Diseases Rickettsiosis Treatment Outcome Immunoglobulin M Doxycycline Immunoglobulin G Tropical medicine Granulomatous Hepatitis Parasitology Female Desert Climate business Q Fever |
| Zdroj: | The American journal of tropical medicine and hygiene. 75(1) |
| ISSN: | 0002-9637 |
| Popis: | Despite the absence of a natural reservoir for Q fever in the desert of Southern California, six cases have been identified during the past 32 years. During that period of time, two areas have been used by northern sheep ranchers from Idaho and Wyoming to import sheep to an area in the Coachella Valley through 1985. Thereafter, because of housing development, the sheep area was moved to Blythe along the Colorado River. All but two of these patients probably acquired infection by Coxiella burnetii by living or working in close proximity to these grazing areas but not directly involved with the sheep. The shift of infected patients from the Coachella Valley to Blythe (100 miles distant) seems to support that supposition. All patients with acute Q fever developed antibodies primarily to phase II antigen, whereas the only person with chronic Q fever developed phase I antibodies. All patients presented with granulomatous hepatitis. One also had a pulmonary infiltrate, and the single individual with chronic Q fever also had a mitral valve prosthesis, although echocardiography could not define endocarditis. All patients with acute infections responded to 3-5 weeks of therapy with doxycycline, whereas the patient with chronic disease failed 3 years of therapy with combination regimens. Further studies at the Eisenhower Medical Center on the prevalence of infection in Blythe, CA, and elsewhere are anticipated. |
| Databáze: | OpenAIRE |
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