Daily Intake of Milk Powder and Risk of Celiac Disease in Early Childhood: A Nested Case-Control Study
| Autor: | Kalle Kurppa, Hye-Seung Lee, Suvi M. Virtanen, Elin M. Hard af Segerstad, Carin Andrén Aronsson, Ingegerd Sjöholm, Jill M. Norris, Daniel Agardh, Marilyn Rayner, Ulla Uusitalo, Jimin Yang |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Pediatrics Tissue transglutaminase Disease HLA-DR3 Antigen Risk Factors Odds Ratio Prospective Studies Age of Onset 2. Zero hunger chemistry.chemical_classification Nutrition and Dietetics biology Infant Formula 3. Good health Europe HLA Phenotype infant feeding Sweden milk powder formula gluten commercial infant foods Child Preschool Female Powders medicine.medical_specialty Human leukocyte antigen Risk Assessment Article 03 medical and health sciences GTP-Binding Proteins HLA-DQ Antigens medicine HLA-DR4 Antigen Humans Genetic Predisposition to Disease Protein Glutamine gamma Glutamyltransferase 2 Seroconversion Birth Year Autoantibodies 030109 nutrition & dietetics Transglutaminases business.industry Infant nutritional and metabolic diseases Odds ratio Gluten United States digestive system diseases Bottle Feeding Celiac Disease Logistic Models chemistry Case-Control Studies Nested case-control study biology.protein business Biomarkers Food Science |
| Zdroj: | Nutrients; Volume 10; Issue 5; Pages: 550 Nutrients |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu10050550 |
| Popis: | Milk powder and gluten are common components in Swedish infants’ diets. Whereas large intakes of gluten early in life increases the risk of celiac disease in genetically at-risk Swedish children, no study has yet evaluated if intake of milk powder by 2 years of age is associated with celiac disease. A 1-to-3 nested case-control study, comprised of 207 celiac disease children and 621 controls matched for sex, birth year, and HLA genotype, was performed on a birth cohort of HLA-DR3-DQ2 and/or DR4-DQ8-positive children. Subjects were screened annually for celiac disease using tissue transglutaminase autoantibodies (tTGA). Three-day food records estimated the mean intake of milk powder at ages 6 months, 9 months, 12 months, 18 months, and 24 months. Conditional logistic regression calculated odds ratios (OR) at last intake prior to seroconversion of tTGA positivity, and for each time-point respectively and adjusted for having a first-degree relative with celiac disease and gluten intake. Intake of milk powder prior to seroconversion of tTGA positivity was not associated with celiac disease (OR = 1.00; 95% CI = 0.99, 1.03; p = 0.763). In conclusion, intake of milk powder in early childhood is not associated with celiac disease in genetically susceptible children. |
| Databáze: | OpenAIRE |
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