Microvascular flow alterations in critically ill COVID-19 patients: A prospective study

Autor: Stéphanie Malaquin, Pierre Alexandre Roger, Yazine Mahjoub, Pierre-Yves Macq, Guillaume Haye, Hervé Dupont, Patricia Besserve, Vincent Jounieaux, Benoit Lecat, Mathieu Guilbart, Sandrine Soriot-Thomas, Osama Abou-Arab, Abdelilah Khalipha, Michael Bernasinski, Christophe Beyls, Pierre Huette
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Viral Diseases
Physiology
medicine.medical_treatment
Hemodynamics
030204 cardiovascular system & hematology
Cardiovascular Physiology
Biochemistry
Norepinephrine
Medical Conditions
Catecholamines
0302 clinical medicine
Medicine and Health Sciences
Prospective Studies
Amines
Prospective cohort study
Virus Testing
Multidisciplinary
Organic Compounds
Neurochemistry
Neurotransmitters
Middle Aged
Hospitals
Pathophysiology
Intensive Care Units
Chemistry
Infectious Diseases
Anesthesia
Blood Circulation
Physical Sciences
Medicine
Female
Research Article
Chemical Elements
Microvascular flow
Biogenic Amines
Coronavirus disease 2019 (COVID-19)
Critical Illness
Partial Pressure
Science
Surgical and Invasive Medical Procedures
World health
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Sepsis
medicine
Humans
Aged
Mechanical ventilation
SARS-CoV-2
business.industry
Critically ill
Microcirculation
Organic Chemistry
Chemical Compounds
COVID-19
Biology and Life Sciences
Covid 19
030208 emergency & critical care medicine
Carbon Dioxide
Hormones
Oxygen
Health Care
Health Care Facilities
Microvessels
Clinical Medicine
Intubation
business
Neuroscience
Zdroj: PLoS ONE, Vol 16, Iss 2, p e0246636 (2021)
PLoS ONE
ISSN: 1932-6203
Popis: Background Data on microcirculatory pattern of COVID-19 critically ill patients are scarce. The objective was to compare sublingual microcirculation parameters of critically ill patients according to the severity of the disease. Methods The study is a single-center prospective study with critically ill COVID-19 patients admitted in ICU. Sublingual microcirculation was assessed by IDF microscopy within 48 hours of ICU admission. Microcirculatory flow index (MFI), proportion of perfused vessel (PPV), total vessel density (TVD), De Backer score (DBS), perfused vessel density (PVD) and heterogeneity index (HI) were assessed. Patients were divided in 2 groups (severe and critical) according to the World health organization definition. Findings From 19th of March to 7th of April 2020, 43 patients were included. Fourteen patients (33%) were in the severe group and twenty-nine patients (67%) in the critical group. Patients in the critical group were all mechanically ventilated. The critical group had significantly higher values of MFI, DBS and PVD in comparison to severe group (respectively, PaCO2: 49 [44–45] vs 36 [33–37] mmHg; p-2; p = 0.033, PVD: 12.5 ± 3.0 vs 10.1 ± 2.4 mm.mm-2; p = 0.020). PPV, HI and TVD were similar between groups Correlation was found between microcirculatory parameters and PaCO2 levels. Conclusion Critical COVID-19 patients under mechanical ventilation seem to have higher red blood cell velocity than severe non-ventilated patients.
Databáze: OpenAIRE
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