The Role of Mannose Receptor on HIV-1 Entry into Human Spermatozoa
| Autor: | María Teresa Rugeles, Albeiro López-Herrera, Paula Andrea Velilla-Hernández, Angela P. Cadavid, Walter Cardona-Maya |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Immunology Human immunodeficiency virus (HIV) HIV Infections Receptors Cell Surface Biology medicine.disease_cause CXCR4 Virus medicine Humans Immunology and Allergy Lectins C-Type Vector (molecular biology) Receptor education education.field_of_study urogenital system virus diseases Obstetrics and Gynecology Sperm receptor Spermatozoa Molecular biology Sperm Mannose-Binding Lectins Reproductive Medicine HIV-1 Mannose Receptor Mannose receptor |
| Zdroj: | American Journal of Reproductive Immunology. 55:241-245 |
| ISSN: | 1600-0897 8755-8920 |
| DOI: | 10.1111/j.1600-0897.2005.00340.x |
| Popis: | In this opinion article we consider the possibility that human spermatozoa have receptors for human immunodeficiency virus-1 (HIV-1). It is clear that sperm cells have the potential for transmitting HIV-1, but the mechanisms responsible for spreading or the virus by this vector are not known. In contrast to the traditional HIV-1 target cells, spermatozoa do not express CD4 receptors or the CCR5/CXCR4 co-receptors. Recent evidence indicates that astrocytes, which also do not express these molecules, can be infected with HIV-1 through the mannose receptor. Furthermore, a 160-kDa sperm receptor that interacts with the HIV gp 120 has been described. Therefore, we hypothesize that the mannose receptor, of 165-175 kDa, is the receptor that HIV-1 uses to invade spermatozoa, which could lead to both vertical and horizontal transmission of HIV-1. |
| Databáze: | OpenAIRE |
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