A Convenient 3-Step Synthesis of 3-Acetamido-6-arylpyridazines Directed to Novel Y5 Receptor Antagonist
| Autor: | Jean-Albert Boutin, Pierre Renard, Yveline Rival, Camille-Georges Wermuth, Sébastien Guery |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Magnetic Resonance Spectroscopy Central nervous system In Vitro Techniques Catalysis Internal medicine Acetamides Drug Discovery medicine Humans Endocrine system Depression (differential diagnoses) Sedentary lifestyle Chemistry Antagonist General Chemistry General Medicine Neuropeptide Y receptor medicine.disease Obesity Receptors Neuropeptide Y Pyridazines medicine.anatomical_structure Endocrinology Anxiety Indicators and Reagents medicine.symptom |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 50:636-639 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.50.636 |
| Popis: | Obesity is a common disorder in the industrialized world. The major environmental factor associated with the rising prevalence of obesity is an increasingly sedentary lifestyle, compounded by greater levels of caloric intake. Recent studies 1—12) have shown that in the central nervous system (CNS), neuropeptide Y (NPY) has been implicated in obesity and feeding, anxiety and depression, endocrine function and metabolism. 1) More particularly it was observed that food intake was inhibited by antisense oligodeoxynucleotides to the |
| Databáze: | OpenAIRE |
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