Evaluation of the deoxyuridine suppression test by using whole blood samples from folic acid-supplemented subjects
| Autor: | Howerde E. Sauberlich, Kenneth D. Hatch, Soong Sj, Philip A. Cole, C. E. Butterworth, Tsunenobu Tamura |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Vitamin
Adult Male medicine.medical_specialty Erythrocytes Medicine (miscellaneous) Nutritional Status chemistry.chemical_compound Random Allocation Folic Acid Oral administration Internal medicine Blood plasma medicine Humans Cyanocobalamin Vitamin B12 Whole blood Nutrition and Dietetics business.industry DNA Middle Aged medicine.disease Uterine Cervical Dysplasia Deoxyuridine Red blood cell Vitamin B 12 Endocrinology medicine.anatomical_structure chemistry Dysplasia Female business Thymidine |
| Zdroj: | The American journal of clinical nutrition. 51(1) |
| ISSN: | 0002-9165 |
| Popis: | We performed the deoxyuridine suppression test (dUST) along with assessment of folate and vitamin B-12 status in blood specimens from 136 normal women and 109 women with cervical dysplasia. All tests were repeated at 2, 4, and 6 mo in subjects with dysplasia during a randomized, double-blind intervention trial in which 50 received a 10-mg daily oral folic acid supplement (F group) and 59 received a placebo (P group). Median folate concentration increased fivefold in plasma and threefold in erythrocytes of F group beginning at the second months and remained elevated whereas concentrations of the P group remained unchanged. Vitamin B-12 values did not vary significantly in either group. The dUST value decreased from 10.4 +/- 4.6% (means +/- SD) pretreatment to 4.5 +/- 4.7% in F group after 2 mo (p less than 0.001). The dUST values had significant negative correlation with plasma and erythrocyte folate concentrations. However, erythrocyte folate had the greatest power to distinguish P group from F group. |
| Databáze: | OpenAIRE |
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