Controlled diazonium electrodeposition towards a biosensor for C-reactive protein
| Autor: | Leena-Sisko Johansson, Liam Gillan, Tuija Teerinen, Maria Smolander |
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| Přispěvatelé: | VTT Technical Research Centre of Finland, Department of Bioproducts and Biosystems, Aalto-yliopisto, Aalto University |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Sensors International, Vol 2, Iss, Pp 100060-(2021) Gillan, L, Teerinen, T, Johansson, L-S & Smolander, M 2021, ' Controlled diazonium electrodeposition towards a biosensor for C-reactive protein ', Sensors International, vol. 2, 100060 . https://doi.org/10.1016/j.sintl.2020.100060 |
| Popis: | Electrografting of aryldiazonium species is useful for linkage between electrochemical transducer surface and biosensor recognition elements. However, the process proceeds uncontrollably to form branched/multilayer growth. This paper reports harnessing steric hindrance for controlled growth of aryldiazonium coupling agent during electrografting to screen-printed carbon electrode surface, which was subsequently used for linkage of CRP recognition elements to form a biosensor with greater sensitivity (32.0 ± 0.5 μA/(ng/mL) than that formed by way of uncontrolled growth (26.6. ± 5.3 μA/(ng/mL) across a highly sensitive operating range of 0.01–10 ng/mL. To the best of our knowledge, this is the first report of this approach demonstrated as a route for biosensor fabrication. This finding suggests the approach can be exploited in immunosensor assays. |
| Databáze: | OpenAIRE |
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