Muscle functions and bone strength are impaired in adolescents with type 1 diabetes
| Autor: | Jana Matyskova, Zdenek Sumnik, Klara Maratova, Lenka Petruzelkova, Stepanka Pruhova, Barbora Obermannova, Zdenek Hlavka, Ondrej Soucek, Stanislava Kolouskova |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Histology Adolescent Physiology Endocrinology Diabetes and Metabolism Osteoporosis 030209 endocrinology & metabolism medicine.disease_cause Bone and Bones Young Adult 03 medical and health sciences 0302 clinical medicine Bone strength Jumping Bone Density Internal medicine medicine Humans Tibia Quantitative computed tomography Bone mineral Type 1 diabetes Anthropometry medicine.diagnostic_test business.industry medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 1 030104 developmental biology Endocrinology Sarcopenia Female Tomography X-Ray Computed business |
| Zdroj: | Bone. 106:22-27 |
| ISSN: | 8756-3282 |
| Popis: | Background Sarcopenia and osteoporosis are among the late complications of type 1 diabetes (T1D) in adults. Whether and to what extent musculoskeletal impairment is present in childhood and adolescence has yet to be determined. The aim of this study was to assess volumetric bone mineral density (BMD) and dynamic muscle function in adolescents with T1D and to assess the clinical and biochemical predictors of their musculoskeletal system. Methods Ninety-five children and adolescents (59 boys and 36 girls, mean age 16.2 ± 1.2 years) with T1D were included in this cross-sectional study. Study participants were divided into two groups according to the duration of the disease ( 9 years, respectively). Volumetric BMD of the non-dominant tibia was assessed using peripheral quantitative computed tomography (pQCT). Dynamic muscle function was evaluated using jumping mechanography. Gender- and height-specific Z-scores were calculated using published reference data. HbA1c was evaluated retrospectively as an average over the past 5 years. Results Relative muscle power (P max /mass) and force (F max /body weight) were significantly decreased in T1D subjects (mean Z-scores − 0.4 ± 1.0; p max /mass (p max /body weight (p = 0.54). Patients with T1D had also decreased trabecular BMD, the Strength-Strain Index and cortical thickness (mean Z-scores − 0.8 ± 1.3; − 0.5 ± 0.8 and − 1.1 ± 0.8, respectively, p Conclusion T1D influences the musculoskeletal system in adolescence. Decreased muscle function could contribute to the osteoporosis reported in adult diabetic patients. |
| Databáze: | OpenAIRE |
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