Chronic demyelinating neuropathy associated with benign IgM paraproteinaemia
| Autor: | P. K. Thomas, R. A. Eames, S. N. Kahn, I. S. Smith, Rosalind H.M. King, D. J. Whybrew, B. W. Lacey |
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| Rok vydání: | 1983 |
| Předmět: |
Male
Pathology medicine.medical_specialty Ataxia Blood Protein Disorders Myelinated nerve fiber Biopsy Motor nerve Fluorescent Antibody Technique Nerve conduction velocity Myelin Nerve Fibers Sural Nerve medicine Humans CSF albumin Aged medicine.diagnostic_test biology business.industry Electromyography Middle Aged Axons Microscopy Electron medicine.anatomical_structure Immunoglobulin M Immunology Chronic Disease biology.protein Female Radial Nerve Neurology (clinical) medicine.symptom business Demyelinating Diseases |
| Zdroj: | Brain : a journal of neurology. 106 |
| ISSN: | 0006-8950 |
| Popis: | Twelve cases of chronic sensorimotor neuropathy associated with benign IgM paraproteinaemia are described. The onset was in the sixth or seventh decades and 9 cases were male. Tremor and ataxia were common features. The ESR was raised in 6 cases and the CSF protein content elevated in 10. There was severe reduction of motor nerve conduction velocity. Sera from all cases contained monoclonal IgM antibodies strongly reactive with human peripheral myelin, made up by the paraprotein. Histological studies on nerve biopsies taken from 8 cases all demonstrated a demyelinating neuropathy. Eight biopsies were examined by immunofluorescence. Monoclonal IgM was present on the myelin sheaths of surviving myelinated nerve fibres. The findings suggested that the neuropathy was of autoimmune origin and caused directly by the antimyelin antibody. |
| Databáze: | OpenAIRE |
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