Detection of visual and frontoparietal network perfusion deficits in Parkinson's disease dementia
| Autor: | Sena Azamat, Ani Kicik, Hasmet Hanagasi, Başar Bilgiç, Emel Erdogdu, Sevim Cengiz, Zeynep Tufekcioglu, Kardelen Eryürek, Tamer Demiralp, Dilek Betul Arslan, Esin Ozturk-Isik, Hakan Gurvit |
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| Přispěvatelé: | Işık Üniversitesi, Fen Edebiyat Fakültesi, Psikoloji Bölümü, Işık University, Faculty of Arts and Sciences, Department of Psychology, Erdoğdu, Emel |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Parkinson's disease Thalamus Mild cognitive impairment with Parkinson's disease (PD-MCI) Perfusion scanning Neuropsychological Tests Arterial Spin Labelling Magnetic Resonance behavioral disciplines and activities Cuneus Internal medicine mental disorders Architecture Pathology Humans Medicine Dementia Cognitive Dysfunction Radiology Nuclear Medicine and imaging Cognitive decline Diagnostic-criteria medicine.diagnostic_test Progression business.industry Parkinson Disease (PD) Resting state functional MRI (rs-fMRI) networks Brain Mild cognitive impairment Parkinson Disease Magnetic resonance imaging General Medicine medicine.disease Magnetic Resonance Imaging Perfusion Hypoperfusion medicine.anatomical_structure Cerebral blood flow Cardiology Parkinson Disease dementia (PDD) business Organization Imaging (ASL-MRI) |
| Popis: | PubMed: ID34619619 Mild cognitive impairment of Parkinson's disease (PD) may be an early manifestation that may progressively worsen to dementia. Cognitive decline has been associated with changes in the brain perfusion pattern. This study aimed to evaluate cerebral blood flow (CBF) deficits specific to different stages of cognitive decline. Seventeen patients with cognitively normal PD (PD-CN), 18 patients with PD with mild cognitive impairment (PD-MCI), and 16 patients with PD with dementia (PDD) were included in this study. The participants were scanned using a 3 T Philips MRI scanner. Arterial spin labelling magnetic resonance (ASL-MR) images were acquired, followed by calculation of the CBF maps, and registration onto the MNI152 brain atlas. A whole-brain voxel-based CBF comparison was performed among the patient groups using age as a covariate. The mean age of patients with PDD was significantly higher than that of patients with PD-MCI (P = 0.015) and PD-CN (P = 0.001). The CBF values of the three groups were significantly different in the left cuneus of the visual network (VN), left inferior frontal gyrus of the frontoparietal network (FPN), and left dorsomedial nucleus of the thalamus. PDD had lower perfusion values than PD-MCI group in the same regions detected in the main group analysis. Additionally, comparison of PDD with PD-CN and non-demented groups revealed that the perfusion reduction extended into the bilateral cuneus of the VN, bilateral thalami, and left inferior frontal gyrus of the FPN. PDD could be separated from PD-MCI and PD-CN stages with CBF deficits in non-dopaminergically mediated posterior and dopaminergically mediated frontal networks. Publisher's Version |
| Databáze: | OpenAIRE |
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