ZNRF3 contributes to the growth of lung carcinoma via inhibiting Wnt/β-catenin pathway and is regulated by miR-93
| Autor: | Xiangao Jiang, Jichan Shi, Zhijie Yu, Yu Hehe, Zhengxing Wu, Guiqing He, Aiqiong Chen, Hongye Ning, Yuwei Cai |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Beta-catenin Lung Neoplasms Ubiquitin-Protein Ligases 03 medical and health sciences Mice 0302 clinical medicine Internal medicine Cell Line Tumor microRNA medicine Carcinoma Animals Humans Lung cancer Wnt Signaling Pathway beta Catenin Cell Proliferation Mice Inbred BALB C biology business.industry Cell growth Wnt signaling pathway Cancer General Medicine respiratory system medicine.disease respiratory tract diseases MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Catenin biology.protein Cancer research Female business |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 37(3) |
| ISSN: | 1423-0380 |
| Popis: | Lung carcinoma is the most common cancer with increasing morbidity, inefficient therapeutic modality, and poor prognosis, due to the lack of understanding of its related molecular mechanism. ZNRF3 is a newly identified negative regulator of Wnt signaling. In this study, we found that ZNRF3 level is reduced in lung carcinoma compared with normal lung tissue and its expression level is positively correlated with the survival of lung cancer patients. Restoration of ZNRF3 suppressed the proliferation and cell cycle progression of lung cancer cell lines. Suppression of ZNRF3 expression in normal lung cells increased the proliferation rates. In an animal model, ZNRF3 was shown to suppress the growth of lung cancer xenografts. ZNRF3 was shown to negatively regulate the activation of Wnt signaling in lung cancerous and normal cells. Further studies revealed that ZNRF3 is a target of miR-93, an oncogenic microRNA (miRNA) for lung cancer progression. Collectively, we found that miR-93/ZNRF3/Wnt/β-catenin regulatory network contributes to the growth of lung carcinoma. Targeting this pathway may be a promising strategy for lung cancer therapy. |
| Databáze: | OpenAIRE |
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