LCK‐Mediated RIPK3 Activation Controls Double‐Positive Thymocyte Proliferation and Restrains Thymic Lymphoma by Regulating the PP2A‐ERK Axis
| Autor: | Sung‐Min Hwang, Yu‐Jin Ha, Gi‐Bang Koo, Hyun‐Jin Noh, A‐Yeon Lee, Byeong‐Ju Kim, Sun Mi Hong, Michael J. Morgan, Seong‐il Eyun, Dakeun Lee, Jae‐Seok Roe, Youngsoo Lee, You‐Sun Kim |
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| Rok vydání: | 2022 |
| Předmět: |
Mice
Knockout Thymocytes Lymphoma General Chemical Engineering General Engineering General Physics and Astronomy Medicine (miscellaneous) Thymus Neoplasms Biochemistry Genetics and Molecular Biology (miscellaneous) Mice Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Receptor-Interacting Protein Serine-Threonine Kinases Animals General Materials Science Protein Phosphatase 2 Extracellular Signal-Regulated MAP Kinases Cell Proliferation |
| Zdroj: | Advanced Science. 9:2204522 |
| ISSN: | 2198-3844 |
| Popis: | Receptor-interacting protein kinase 3 (RIPK3) is the primary regulator of necroptotic cell death. RIPK3 expression is often silenced in various cancer cells, which suggests that it may have tumor suppressor properties. However, the exact mechanism by which RIPK3 negatively regulates cancer development and progression remains unclear. This report indicates that RIPK3 acts as a potent regulator of the homeostatic proliferation of CD4 |
| Databáze: | OpenAIRE |
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