Achiote (Bixa orellana) Lipophilic Extract, Bixin, and δ-tocotrienol Effects on Lifespan and Stress Resistance in Caenorhabditis elegans
| Autor: | Silvestre Alavez, Angélica Román-Guerrero, Luis Pinzón-López, Laura J. Pérez-Flores, Arturo Navarro-Ocaña, Darío R. Gómez-Linton |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
medicine.medical_treatment Longevity Pharmaceutical Science Pharmacology Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Nutraceutical Drug Discovery medicine Animals Vitamin E Caenorhabditis elegans Caenorhabditis elegans Proteins Carotenoid 030304 developmental biology chemistry.chemical_classification 0303 health sciences biology Plant Extracts Insulin Organic Chemistry Bixin Bixaceae biology.organism_classification Carotenoids Oxidative Stress Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis Molecular Medicine Tocotrienol |
| Zdroj: | Planta medica. 87(5) |
| ISSN: | 1439-0221 |
| Popis: | The onset of many degenerative diseases related to aging has been associated with a decrease in the activity of antistress systems, and pharmacological interventions increasing stress resistance could be effective to prevent the development of such diseases. Achiote is a valuable source of carotenoid and tocotrienols, which have antioxidant activity. In this work, we explore the capacity of an achiote seed extract and its main compounds to modulate the lifespan and antistress responses on Caenorhabditis elegans, as well as the mechanisms involved in these effects. Achiote lipophilic extract, bixin, and δ-tocotrienol were applied on nematodes to carry out lifespan, stress resistance, and fertility assays. The achiote seed extract increased the median and maximum lifespan up to 35% and 27% and increased resistance against oxidative and thermal stresses without adverse effects on fertility. The beneficial effects were mimicked by a bixin+δ-tocotrienol mixture. All the effects on lifespan and stress resistance were independent of caloric restriction but dependent on the insulin/insulin growth factor-1 pathway. This study could provide insights for further research on a new beneficial use of this important crop in health and nutraceutical applications beyond its use as a source of natural pigments. |
| Databáze: | OpenAIRE |
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